Evaluation of the hepatoprotective activity of standardized ethanolic extract of Curcuma xanthorrhiza Roxb.

被引：12

作者：

Devaraj, Sutha ^{[1
]}

Ismail, Sabariah ^{[1
]}

Ramanathan, Surash ^{[1
]}

Marimuthu, Santhini ^{[2
]}

Fei, Yam Mun ^{[3
]}

机构：

[1] Univ Sains Malaysia, Ctr Drug Res, George Town 11800, Malaysia

[2] Univ Sains Malaysia, Sch Biol Sci, George Town 11800, Malaysia

[3] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

来源：

JOURNAL OF MEDICINAL PLANTS RESEARCH | 2010年 / 4卷 / 23期

关键词：

Curcuma xanthorrhiza; hepatoprotective activity; ethanol; serum enzyme; LIVER-INJURY; CONSUMPTION;

D O I：

10.5897/JMPR10.453

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Curcuma xanthorrhiza is widely used in Indonesia folk medicine to treat liver disorders. This study has evaluated the hepatoprotective activity of standardized ethanolic extract of C. xanthorrhiza. The extract was standardized using GC-MS. The hepatoprotective activity of this extract was studied using ethanol-induced liver toxicity in rats. This respective activity was assessed through monitoring liver function tests through the measurement of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and protein content. Further, hepatic tissues were also subjected to histopathological studies. Pretreatment of the standardized C. xanthorrhiza ethanolic extract (500 mg/kg) reduced the fatty liver symptoms and significantly (p < 0.05) inhibit the increase of respective serum enzyme levels. The results of the present study indicated that C. xanthorrhiza possess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases.

引用

页码：2512 / 2517

页数：6

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