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Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat
被引:22
|作者:
Becker, C
Hamon, M
Benoliel, JJ
机构:
[1] Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France
[2] Fac Med Pitie Salpetriere, Serv Biochim Med, F-75634 Paris, France
关键词:
cholecystokinin;
in vivo microdialysis;
frontal cortex;
5-H-1A receptor agonists;
restraint stress;
yohimbine-induced anxiety related behaviour;
D O I:
10.1016/S0028-3908(98)00209-3
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an 'anxiogenic' drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam. Here, we investigated whether other anxiolytic drugs such as 5-HT1A receptor agonists could also affect cortical CCKLM release. Indeed, neither buspirone (1 mg/kg i.p.), alnespirone (1 mg/kg i.p.) nor lesopitron (3 mg/kg i.p.) affected, on their own, CCKLM release. However, pretreatment with the latter drugs completely abolished the stimulatory effect of restraint stress on the peptide outflow. As expected of the involvement of 5-HT1A receptors, tertatolol (10 mg/kg i.p) markedly reduced the inhibitory effect of buspirone on restraint stress-evoked CCKLM overflow. On the other hand, pretreatment with buspirone, alnespirone or lesopitron also inhibited the stimulatory effect of yohimbine (5 mg/kg i.p.) on cortical CCKLM outflow. These data support the idea that the anxiolytic action of 5-HT1A receptor agonists could be mediated, at least partly, through their inhibitory influence on cortical CCK-ergic systems. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:525 / 532
页数:8
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