Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration

被引：237

作者：

Fu, ShaoZhi ^{[1
]}

Ni, PeiYan ^{[1
]}

Wang, BeiYu ^{[1
]}

Chu, BingYang ^{[1
]}

Zheng, Lan ^{[1
]}

Luo, Feng ^{[1
]}

Luo, JingCong ^{[1
]}

Qian, ZhiYong ^{[1
]}

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, W China Hosp, W China Med Sch, Chengdu 610041, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 19期

关键词：

Injectable; PECE/Collagen/n-HA hydrogel composite; Thermo-sensitivity; Biocompatibility; Cranial defect; Bone regeneration; TRIBLOCK COPOLYMER; IN-VIVO; TISSUE; SCAFFOLDS; DELIVERY; DIFFERENTIATION; NANOCOMPOSITES; BIOMATERIALS;

D O I：

10.1016/j.biomaterials.2012.03.040

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel three-component biomimetic hydrogel composite was successfully prepared in this study, which was composed of triblock PEG-PCL-PEG copolymer (PECE), collagen and nano-hydroxyapatite (n-HA). The microstructure and thermo-responsibility of the obtained PECE/Collagen/n-HA hydrogel composite were characterized. Scanning electronic microscopy (SEM) showed that the composite exhibited an interconnected porous structure. The rheological analysis revealed that the composite existed good thermo-sensitivity. In vivo biocompatibility and biodegradability was investigated by implanting the hydrogel composite in muscle pouches of rats for 3, 7, and 14 days. Moreover, the osteogenic capacity was evaluated by means of implanting the composite material in cranial defects of New Zealand White rabbits for 4, 12 and 20 weeks. In vivo performances confirmed that the biodegradable PECE/Collagen/n-HA hydrogel composite had good biocompatibility and better performance in guided bone regeneration than the self-healing process. Thus the thermal-response PECE/Collagen/n-HA hydrogel composite had the great potential in bone tissue engineering. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4801 / 4809

页数：9

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