Status and Development of The Tumor Microenvironment in Hepatocellular Carcinoma

被引：1
|
作者：
Liu Zhi-Lei [2 ,3 ]
Sun Wei [2 ,3 ]
He Fu-Chu [3 ]
Cong Xian-Ling [1 ]
Jiang Ying [2 ,3 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Changchun 130031, Peoples R China
[2] Anhui Med Univ, Grad Dept, Hefei 230032, Peoples R China
[3] Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 102206, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 39卷 / 05期
基金：
中国国家自然科学基金;
关键词：
hepatocellucar carcinoma; tumor microenvironment; tissue interstitial fluid (TIF); ENDOTHELIAL GROWTH-FACTOR; HEPATIC STELLATE CELLS; INTERSTITIAL FLUID; MATRIX METALLOPROTEINASES; PROGNOSTIC-SIGNIFICANCE; MESENCHYMAL TRANSITION; NECROSIS-FACTOR; KUPFFER CELL; TGF-BETA; CANCER;
D O I：
10.3724/SP.J.1206.2011.00383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A large quantity of literature highlights the interaction between tumor cells and the surrounding microenvironment which is a very important modulator of the processes in hepatocarcinogenesis. The microenvironment of hepatocellular carcinoma (HCC) can be obviously classified into cellular and produced non-cellular components, including hepatic stellate cells, tumor associated fibroblasts, immune cells and sinusoidal endothelial cells, extracellular matrix (ECM) proteins, growth factors and inflammatory cytokines which play an important role in the development and metastasis of HCC. In this review, we discuss the current cross-talk about the tumor microenvironment and tumor cells in pathogenesis of HCC.
引用
收藏
页码：416 / 422
页数：7
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