Substantia nigra echogenicity in Parkinson's disease: relation to serum iron and C-reactive protein

被引：12
作者：
Walter, Uwe [1 ]
Witt, Rike [1 ]
Wolters, Alexander [1 ]
Wittstock, Matthias [1 ]
Benecke, Reiner [1 ]
机构：
[1] Univ Rostock, Dept Neurol, D-18147 Rostock, Germany
来源：
JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 01期
关键词：
Parkinson's disease; Chronic inflammation; Iron metabolism; Substantia nigra; Transcranial ultrasound; TRANSCRANIAL SONOGRAPHY; MOVEMENT-DISORDERS; HYPERECHOGENICITY; ASSOCIATION; METABOLISM; DIAGNOSIS; ACCURACY; PATHWAYS; MARKER; DAMAGE;
D O I：
10.1007/s00702-011-0664-z
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In Parkinson's disease (PD), substantia nigra hyperechogenicity (SN-h) has been related to both, local iron accumulation and microglia activation. We analysed its relationship in PD patients with serum iron (n = 31) and C-reactive protein (CRP; n = 193). SN-h correlated with lower CRP and iron levels. Also, patients with a first-degree relative with PD had lower iron levels. Microglia activation, if reflected by SN-h, may be therefore unrelated to serum CRP. Findings support the idea that SN-h indicates inherited alteration of iron metabolism.
引用
收藏
页码：53 / 57
页数：5
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