Laboratory diagnosis of antiphospholipid syndrome: From criteria to practice

被引：15
作者：
Joste, V. [1 ]
Dragon-Durey, M. -A. [2 ]
Darnige, L. [1 ]
机构：
[1] Hop Europeen Georges Pompidou, Serv Hematol Biol, 20-40 Rue Leblanc, F-75908 Paris 15, France
[2] Hop Europeen Georges Pompidou, Lab Immunol, 20-40 Rue Leblanc, F-75908 Paris 15, France
来源：
REVUE DE MEDECINE INTERNE | 2018年 / 39卷 / 01期
关键词：
Antiphospholipid syndrome; Antiphospholipid antibodies; Anticardiolipin antibodies; Anti-beta 2-glycoprotein I antibodies; Lupus anticoagulant; INTERNATIONAL CONSENSUS STATEMENT; LUPUS-ANTICOAGULANT; CLASSIFICATION CRITERIA; ANTIPHOSPHATIDYLETHANOLAMINE ANTIBODIES; I ANTIBODIES; DOMAIN-I; THROMBOSIS; MULTICENTER; RISK; ASSOCIATION;
D O I：
10.1016/j.revmed.2017.02.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antiphospholipid syndrome is a bioclinical entity defined by thrombosis and/or obstetrical complications in the presence, at least 12 weeks apart, of antiphospholipid antibodies detected by coagulation test (lupus anticoagulant) or immunological assays (anticardiolipin, anti-beta 2-glycoprotein I antibodies). Biological markers' improvement such as anti-phosphatidylserine/prothrombin and biological score should allow better patients' management and preventive therapeutic for thrombosis and obstetrical complications. This review describes different types of antibodies, link between biological profile and risk level of thrombosis events/obstetrical complitations and gives practical advice to interpret biological results. (C) 2017 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：34 / 41
页数：8
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