GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis

被引：194

作者：

Ye, Qing-Hai ^{[1
]}

Zhu, Wen-Wei ^{[1
,2
]}

Zhang, Ju-Bo ^{[1
,8
]}

Qin, Yi ^{[3
,7
]}

Lu, Ming ^{[2
]}

Lin, Guo-Ling ^{[1
]}

Guo, Lei ^{[1
]}

Zhang, Bo ^{[1
]}

Lin, Zhen-Hai ^{[1
]}

Roessler, Stephanie ^{[4
,6
]}

Forgues, Marshonna ^{[4
]}

Jia, Hu-Liang ^{[2
]}

Lu, Lu ^{[2
]}

Zhang, Xiao-Fei ^{[2
]}

Lian, Bao-Feng ^{[5
]}

Xie, Lu ^{[5
]}

Dong, Qiong-Zhu ^{[2
,3
]}

Tang, Zhao-You ^{[1
,2
]}

Wang, Xin Wei ^{[4
]}

Qin, Lun-Xiu ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Liver Canc Inst, Shanghai 200032, Peoples R China

[2] Fudan Univ, Canc Metastasis Inst, Huashan Hosp, Dept Gen Surg, 12 Urumqi Rd M, Shanghai 200040, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[4] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA

[5] Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China

[6] Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany

[7] Fudan Univ, Dept Pancreat & Hepatobiliary Surg, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[8] Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai 200040, Peoples R China

来源：

CANCER CELL | 2016年 / 30卷 / 03期

关键词：

RECEPTOR TYROSINE KINASES; GOLGI-APPARATUS; CANCER; TRAFFICKING; INTEGRIN; ACTIVATION; GROWTH; FIBROBLASTS; ENDOCYTOSIS; INHIBITION;

D O I：

10.1016/j.ccell.2016.07.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC.

引用

页码：444 / 458

页数：15

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