Basic concepts in the study of diseases with complex genetics

被引：53
作者：
Burmeister, M [1 ]
机构：
[1] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA
来源：
BIOLOGICAL PSYCHIATRY | 1999年 / 45卷 / 05期
关键词：
complex genetics; psychiatric genetics; association; linkage;
D O I：
10.1016/S0006-3223(98)00316-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Most diseases run in families-this is also true of virtually all psychiatric disorders. Twin and adoption studies have shown that most psychiatric disorders have a genetic component, yet very few genetic factors are known, as is true for most disorders with a complex genetic origin. Here I review for nongeneticists, some of the basic terminology and concepts used when studying complex genetic diseases, with examples from psychiatric genetics. This review is intended to help in the understanding and critical evaluation of reports on genetics of psychiatric illnesses in the literature. Biol Psychiatry 1999;45: 522-532 (C) 1999 Society of Biological Psychiatry.
引用
收藏
页码：522 / 532
页数：11
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