Enzyme function and its evolution

被引：12

作者：

Mitchell, John B. O. ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM Sch Chem & Biomed Sci Res Complex, St Andrews KY16 9ST, Fife, Scotland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2017年 / 47卷

关键词：

PROTEIN FUNCTION; STRUCTURAL CLASSIFICATION; FUNCTION PREDICTION; GENE ONTOLOGY; MECHANISM; ANNOTATIONS; HOMOLOGY; ORIGIN; SCOP;

D O I：

10.1016/j.sbi.2017.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With rapid increases over recent years in the determination of protein sequence and structure, alongside knowledge of thousands of enzyme functions and hundreds of chemical mechanisms, it is now possible to combine breadth and depth in our understanding of enzyme evolution. Phylogenetics continues to move forward, though determining correct evolutionary family trees is not trivial. Protein function prediction has spawned a variety of promising methods that offer the prospect of identifying enzymes across the whole range of chemical functions and over numerous species. This knowledge is essential to understand antibiotic resistance, as well as in protein re-engineering and de novo enzyme design.

引用

页码：151 / 156

页数：6

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