Advances in mass spectrometry-based omics analysis of trace organics in water

被引:7
作者
Tang, Yanan [1 ]
Craven, Caley B. [2 ,3 ]
Wawryk, Nicholas J. P. [2 ]
Qiu, Junlang [2 ]
Li, Feng [4 ]
Li, Xing-Fang [2 ]
机构
[1] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Sichuan, Peoples R China
[2] Univ Alberta, Dept Lab Med & Pathol, Div Analyt & Environm Toxicol, Fac Med & Dent, Edmonton, AB T6G 2G3, Canada
[3] Univ Alberta, Dept Chem, Fac Sci, Edmonton, AB T6G 2G2, Canada
[4] Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China
基金
加拿大自然科学与工程研究理事会;
关键词
Mass spectrometry; Omics strategy; Nontargeted analysis; Water analysis; Omics screening; Targeted analysis; SOLID-PHASE MICROEXTRACTION; DISINFECTION BY-PRODUCTS; LIQUID-CHROMATOGRAPHY; DRINKING-WATER; RETENTION TIME; ORGANOPHOSPHORUS PESTICIDES; RIVER WATER; IDENTIFICATION; CONTAMINANTS; PREDICTION;
D O I
10.1016/j.trac.2020.115918
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Driven by the development of mass spectrometry (MS), omics strategies become powerful tools for comprehensive analysis of organics in water. Various separation and ionization techniques have been developed in recent years for MS based omics analysis of water to achieve better resolution, sensitivity, and throughput. Additionally, advances in computer algorithms and enlargement of online databases have enabled batch processing of massive amounts of MS data, drastically shortening analysis time and increasing compound coverage. With such improvements, omics screening of organics in water becomes feasible, leading to high throughput analysis that can tentatively identify thousands of unknowns in a single run. Targeted analysis utilizes existing information of selected compounds to narrow scan ranges, collect further data on selected analytes and quantify these target compounds. Herein, we review recent advances in MS-based omics strategies integrating nontargeted and targeted techniques for analysis of organics in water and discuss existing challenges and future trends. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数:9
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