Tanibirumab (TTAC-0001): A Fully Human Monoclonal Antibody Targets Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2)

被引：29

作者：

Lee, Sang Hoon ^{[1
]}

机构：

[1] PharmAbcine, Taejon 305811, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 08期

关键词：

TUMOR ANGIOGENESIS; THERAPY; DISEASE;

D O I：

10.1007/s12272-011-0821-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vascular endothelial growth factor (VEGF) binds to its receptor (VEGFR) and stimulates angiogenesis, an important step in tumor growth and metastasis. Several anticancer therapies targeting VEGFR with small molecules and antibody have been currently studied in preclinical and clinical studies. This article provides a review of human monoclonal antibody tanibirumab (TTAC-0001), which specifically binds VEGFR-2 and is currently being developed in preclinical stage by PharmAbcine (Daejon, Korea).

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页码：1223 / 1226

页数：4

相关论文

共 16 条

[1] Oncogenic kinase signalling [J].

Blume-Jensen, P ;

Hunter, T .

NATURE, 2001, 411 (6835) :355-365

[2] Angiogenesis in life, disease and medicine [J].

Carmeliet, P .

NATURE, 2005, 438 (7070) :932-936

[3]

Chu QSC, 2009, EXPERT OPIN BIOL TH, V9, P263, DOI [10.1517/14712590802666397 , 10.1517/14712590802666397]

[4] VEGF: an update on biological and therapeutic aspects [J].

Farrara, N .

CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (06) :617-624

[5] The role of vascular endothelial growth factor in angiogenesis [J].

Ferrara, N ;

Gerber, HP .

ACTA HAEMATOLOGICA, 2001, 106 (04) :148-156

[6] Angiogenesis as a therapeutic target [J].

Ferrara, N ;

Kerbel, RS .

NATURE, 2005, 438 (7070) :967-974

[7] ANGIOGENESIS IN CANCER, VASCULAR, RHEUMATOID AND OTHER DISEASE [J].

FOLKMAN, J .

NATURE MEDICINE, 1995, 1 (01) :27-31

[8]

Gerber HP, 2005, CANCER RES, V65, P671

[9] Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis [J].

Hicklin, DJ ;

Ellis, LM .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (05) :1011-1027

[10] VEGF-Trap: A VEGF blocker with potent antitumor effects [J].

Holash, J ;

Davis, S ;

Papadopoulos, N ;

Croll, SD ;

Ho, L ;

Russell, M ;

Boland, P ;

Leidich, R ;

Hylton, D ;

Burova, E ;

Ioffe, E ;

Huang, T ;

Radziejewski, C ;

Bailey, K ;

Fandl, JP ;

Daly, T ;

Wiegand, SJ ;

Yancopoulos, GD ;

Rudge, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :11393-11398