Highly Active Antiretroviral Therapy Versus Zidovudine for Prevention of Mother-to-Child Transmission in a Programmatic Setting, Botswana

被引：13

作者：

Dryden-Peterson, Scott ^{[1
,2
,3
]}

Jayeoba, Oluwemimo ^{[2
]}

Hughes, Michael D. ^{[4
]}

Jibril, Haruna ^{[5
]}

Keapoletswe, Koona ^{[5
]}

Tlale, Josephine ^{[5
]}

Modise, Taolo A. ^{[2
]}

Asmelash, Aida ^{[2
]}

Moyo, Sikhulile ^{[2
]}

van Widenfelt, Erik ^{[2
]}

Makhema, Joseph ^{[2
]}

Essex, Max ^{[2
,3
]}

Shapiro, Roger L. ^{[2
,3
]}

Lockman, Shahin ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA

[2] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana

[3] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Minist Hlth, Dept HIV AIDS Prevent & Care, Gaborone, Botswana

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2011年 / 58卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTION; PREGNANCY; REGIMENS; DISEASE; TRIAL; WOMEN; LOAD;

D O I：

10.1097/QAI.0b013e31822d4063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Few studies have compared the programmatic effectiveness of the recommended strategies of antenatal highly active antiretroviral therapy (HAART) and zidovudine for prevention of mother-to-child transmission. We prospectively followed infants (93% formula fed) whose mothers who took either HAART (258 infants) or zidovudine (170 infants) during pregnancy in the Botswana national program. Overall, 10 infants (2.5%) acquired HIV-9 infants in the zidovudine group (5.5%, 95% confidence interval: 2.6% to 10.2%) and 1 infant in the HAART group (0.4%, 95% confidence interval: 0.0% to 2.2%). Maternal HAART was associated with decreased prevention of mother-to-child transmission (P = 0.001) and improved HIV-free survival (P = 0.040) compared with zidovudine (with or without single-dose nevirapine) in a programmatic setting.

引用

页码：353 / 357

页数：5

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