Zika virus - reigniting the TORCH

被引：259
作者：
Coyne, Carolyn B. [1 ,2 ]
Lazear, Helen M. [3 ]
机构：
[1] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA 15219 USA
[2] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Magee Womens Res Inst, Pittsburgh, PA 15213 USA
[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2016年 / 14卷 / 11期
基金：
美国国家卫生研究院;
关键词：
MALE SEXUAL TRANSMISSION; UPDATE INTERIM GUIDANCE; TO-CHILD TRANSMISSION; PLACENTAL-TRANSFER; UNITED-STATES; ANIMAL-MODELS; GLOBAL BURDEN; 1ST TRIMESTER; INFECTION; DENGUE;
D O I：
10.1038/nrmicro.2016.125
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The recent association between Zika virus (ZIKV) infection during pregnancy and fetal microcephaly has led to a renewed interest in the mechanisms by which vertically transmitted microorganisms reach the fetus and cause congenital disease. In this Opinion article, we provide an overview of the structure and cellular composition of the human placenta and of the mechanisms by which traditional 'TORCH' pathogens (Toxoplasma gondii, other, rubella virus, cytomegalovirus and herpes simplex virus) access the fetal compartment. Based on our current understanding of ZIKV pathogenesis and the developmental defects that are caused by fetal ZIKV infection, ZIKV should be considered a TORCH pathogen and future research and public health measures should be planned and implemented accordingly.
引用
收藏
页码：707 / 715
页数：9
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