Current perspectives on the clinical implications of oxidative RNA damage in aging research: challenges and opportunities

被引：36

作者：

Xu, Zhijie ^{[1
,2
]}

Huang, Jinzhou ^{[2
]}

Gao, Ming ^{[2
]}

Guo, Guijie ^{[2
]}

Zeng, Shuangshuang ^{[3
,4
]}

Chen, Xi ^{[3
,4
]}

Wang, Xiang ^{[3
,4
]}

Gong, Zhicheng ^{[3
,4
]}

Yan, Yuanliang ^{[3
,4
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha 410008, Hunan, Peoples R China

[2] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Dept Oncol, Rochester, MN 55905 USA

[3] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha 410008, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China

来源：

GEROSCIENCE | 2021年 / 43卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Oxidative stress; RNA damage; RNA control systems; Aging; Disorders; BRAIN MITOCHONDRIAL DECAY; GENERATED DNA/RNA DAMAGE; MESSENGER-RNA; RIBOSOMAL-RNA; ALZHEIMERS-DISEASE; 8-OXOGUANINE-CONTAINING RNA; CEREBROSPINAL-FLUID; URINARY MARKERS; QUALITY-CONTROL; GINKGOLIDE B;

D O I：

10.1007/s11357-020-00209-w

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Ribonucleic acid (RNA) molecules can be easily attacked by reactive oxygen species (ROS), which are produced during normal cellular metabolism and under various oxidative stress conditions. Numerous findings report that the amount of cellular 8-oxoG, the most abundant RNA damage biomarker, is a promising target for the sensitive measurement of oxidative stress and aging-associated diseases, including neuropsychiatric disorders. Most importantly, available data suggest that RNA oxidation has important implications for various signaling pathways and gene expression regulation in aging-related diseases, highlighting the necessity of using combinations of RNA oxidation adducts in both experimental studies and clinical trials. In this review, we primarily describe evidence for the effect of oxidative stress on RNA integrity modulation and possible quality control systems. Additionally, we discuss the profiles and clinical implications of RNA oxidation products that have been under intensive investigation in several aging-associated medical disorders.

引用

页码：487 / 505

页数：19

共 132 条

[21] Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS [J].

Chang, Yueming ;

Kong, Qiongman ;

Shan, Xiu ;

Tian, Guilian ;

Ilieva, Hristelina ;

Cleveland, Don W. ;

Rothstein, Jeffrey D. ;

Borchelt, David R. ;

Wong, Philip C. ;

Lin, Chien-liang Glenn .

PLOS ONE, 2008, 3 (08)

[22] Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research [J].

Csiszar, Anna ;

Balasubramanian, Priya ;

Tarantini, Stefano ;

Yabluchanskiy, Andriy ;

Zhang, Xin A. ;

Springo, Zsolt ;

Benbrook, Doris ;

Sonntag, William E. ;

Ungvari, Zoltan .

GEROSCIENCE, 2019, 41 (02) :209-227

[23] Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells [J].

Dai, Da-Peng ;

Gan, Wei ;

Hayakawa, Hiroshi ;

Zhu, Jia-Lou ;

Zhang, Xiu-Qing ;

Hu, Guo-Xin ;

Xu, Tao ;

Jiang, Zhe-Li ;

Zhang, Qun ;

Hu, Xue-Da ;

Nie, Ben ;

Zhou, Yue ;

Li, Jin ;

Zhou, Xiao-Yang ;

Li, Jian ;

Zhang, Tie-Mei ;

He, Qing ;

Liu, Dong-Ge ;

Chen, Hai-Bo ;

Yang, Nan ;

Zuo, Ping-Ping ;

Zhang, Zhi-Xin ;

Yang, Huan-Ming ;

Wang, Yao ;

Wilson, Samuel H. ;

Zeng, Yi-Xin ;

Wang, Jian-Ye ;

Sekiguchi, Mutsuo ;

Cai, Jian-Ping .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (16) :4218-4222

[24] Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1 [J].

De Luca, Gabriele ;

Ventura, Ilenia ;

Sanghez, Valentina ;

Russo, Maria Teresa ;

Ajmone-Cat, Maria Antonietta ;

Cacci, Emanuele ;

Martire, Alberto ;

Popoli, Patrizia ;

Falcone, Germana ;

Michelini, Flavia ;

Crescenzi, Marco ;

Degan, Paolo ;

Minghetti, Luisa ;

Bignami, Margherita ;

Calamandrei, Gemma .

AGING CELL, 2013, 12 (04) :695-705

[25] RNA base damage and repair [J].

Feyzi, Emadoldin ;

Sundheim, Ottar ;

Westbye, Marianne Pedersen ;

Aas, Per Arne ;

Vagbo, Cathrine B. ;

Otterlei, Marit ;

Slupphaug, Geir ;

Krokan, Hans E. .

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2007, 8 (06) :326-331

[26] Role of Oxidative RNA Damage in Chronic-Degenerative Diseases [J].

Fimognari, Carmela .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 2015

[27] Sulforaphane Potentiates RNA Damage Induced by Different Xenobiotics [J].

Fimognari, Carmela ;

Lenzi, Monia ;

Sestili, Piero ;

Turrini, Eleonora ;

Ferruzzi, Lorenzo ;

Hrelia, Patrizia ;

Cantelli-Forti, Giorgio .

PLOS ONE, 2012, 7 (04)

[28] Suppression of DNA/RNA and protein oxidation by dietary supplement which contains plant extracts and vitamins: a randomized, double-blind, placebo-controlled trial [J].

Fragopoulou, Elizabeth ;

Gavriil, Lamprini ;

Argyrou, Chrysa ;

Malagaris, Ioannis ;

Choleva, Maria ;

Antonopoulou, Smaragdi ;

Afxentiou, Georgia ;

Nikolaou, Eleana .

LIPIDS IN HEALTH AND DISEASE, 2018, 17

[29] Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide [J].

Freudenthal, Bret D. ;

Beard, William A. ;

Perera, Lalith ;

Shock, David D. ;

Kim, Taejin ;

Schlick, Tamar ;

Wilson, Samuel H. .

NATURE, 2015, 517 (7536) :635-U261

[30] A Novel Class of mRNA-containing Cytoplasmic Granules Are Produced in Response to UV-Irradiation [J].

Gaillard, Helene ;

Aguilera, Andres .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (11) :4980-4992

← 1 2 3 4 5 6 7 8 9 10 →