Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus

被引:37
|
作者
Bledsoe, Adam C. [1 ]
Oliver, Kathryn M. [1 ]
Scholl, Jamie L. [1 ]
Forster, Gina L. [1 ]
机构
[1] Univ S Dakota, Neurosci Grp, Div Basic Biomed Sci, Sanford Sch Med, Vermillion, SD 57069 USA
关键词
Social isolation; Corticotropin-releasing factor; Anxiety; Antisauvagine-30; Antalarmin; Elevated plus maze; CORTICOTROPIN-RELEASING-FACTOR; ELEVATED X-MAZE; TYPE-2; RECEPTORS; BEHAVIOR; SEROTONIN; RESPONSES; STRESS; BRAIN; RATS; NEUROENDOCRINE;
D O I
10.1016/j.brainresbull.2011.03.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Post-weaning social isolation of rats is utilized as a model of early life stress. We have previously demonstrated that rats exposed to post-weaning social isolation exhibit greater anxiety-like behaviors as adults. Furthermore, these rats exhibit greater density of corticotropin-releasing factor (CRF) type 2 receptors in the dorsal raphe nucleus. Therefore, we examined whether antagonism of CRF2 receptors in the dorsal raphe nucleus reverses the effects of post-weaning social isolation on anxiety states. Male rats were reared in isolation or in groups from day of weaning (postnatal day [PND] 21) to mid-adolescence (PND42) and then allowed to develop to early adulthood housed in groups. At PND62, rats were either infused with vehicle, the CRF1 receptor antagonist antalarmin (0.25-0.5 mu g) or the CRF2 receptor antagonist antisauvagine-30 (2 mu g) into the dorsal raphe nucleus, 20 min prior to being introduced to the elevated plus maze. Isolation-reared rats showed reduced open arm behavior compared to group-reared rats, confirming the anxiogenic effects of post-weaning social isolation. Infusion of the CRF2 receptor antagonist, but not the CRF1 receptor antagonist, into the dorsal raphe nucleus of isolation-reared rats increased open arm behavior when compared to that of group-reared rats. Overall, the findings suggest that CRF2 receptors within the dorsal raphe nucleus mediate anxiety-like states following post-weaning social isolation, and CRF2 receptors may represent an important target for the treatment of anxiety disorders following early life stressors. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:117 / 122
页数:6
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