Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats

被引：16

作者：

Andreazzi, Ana Eliza ^{[1
]}

Grassiolli, Sabrina ^{[2
]}

Marangon, Paula Beatriz ^{[2
]}

Martins, Adriana Gallego ^{[2
]}

de Oliveira, Julio Cezar ^{[2
]}

Torrezan, Rosana ^{[2
]}

Gravena, Clarice ^{[2
]}

Gonzalez Garcia, Raul Marcel ^{[3
]}

de Freitas Mathias, Paulo Cezar ^{[2
]}

机构：

[1] Univ Fed Juiz de Fora, Dept Physiol, Physiol Lab, BR-36036900 Juiz De Fora, MG, Brazil

[2] Univ Estadual Maringa, Dept Cell Biol & Genet, Lab Secret Cell Biol, BR-87020900 Maringa, Parana, Brazil

[3] Univ Fed Juiz de Fora, Dept Biol, Cell Biol Lab, BR-36036900 Juiz De Fora, MG, Brazil

来源：

EXPERIMENTAL DIABETES RESEARCH | 2011年

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; MONOSODIUM-L-GLUTAMATE; ADRENAL CHROMAFFIN CELLS; REDUCED NOREPINEPHRINE TURNOVER; BROWN ADIPOSE-TISSUE; MSG-TREATED-RATS; PROTEIN-KINASE-C; ENERGY HOMEOSTASIS; PANCREATIC-ISLETS; BETA-CELL;

D O I：

10.1155/2011/947917

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The involvement of sympathoadrenal axis activity in obesity onset was investigated using the experimental model of treating neonatal rats with monosodium L-glutamate. To access general sympathetic nervous system activity, we recorded the firing rates of sympathetic superior cervical ganglion nerves in animals. Catecholamine content and secretion from isolated adrenal medulla were measured. Intravenous glucose tolerance test was performed, and isolated pancreatic islets were stimulated with glucose and adrenergic agonists. The nerve firing rate of obese rats was decreased compared to the rate for lean rats. Basal catecholamine secretion decreased whereas catecholamine secretion induced by carbachol, elevated extracellular potassium, and caffeine in the isolated adrenal medulla were all increased in obese rats compared to control. Both glucose intolerance and hyperinsulinaemia were observed in obese rats. Adrenaline strongly inhibited glucose-induced insulin secretion in obese animals. These findings suggest that low sympathoadrenal activity contributes to impaired glycaemic control in prediabetic obese rats.

引用

页数：11

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