Characterization of chemical constituents in Shuanghuanglian oral dosage forms by ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry

被引：20

作者：

Li, Ruiyun ^{[1
]}

Zhu, Yanru ^{[1
]}

Ma, Mingyan ^{[2
]}

Lei, Min ^{[3
]}

Zhao, Yingchun ^{[4
]}

Liu, Ting ^{[5
]}

Yu, Miao ^{[1
]}

Zhao, Yunli ^{[1
]}

Yu, Zhiguo ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China

[2] Zhejiang Pharmaceut Coll, Fac Pharm, Ningbo, Peoples R China

[3] SCIEX Analyt Instrument Trading Co Ltd, Shanghai Off, Shanghai, Peoples R China

[4] Shenyang Inst Food & Drug Control, Shenyang, Peoples R China

[5] Shenyang Med Coll, Sch Pharm, Shenyang, Peoples R China

来源：

JOURNAL OF SEPARATION SCIENCE | 2022年 / 45卷 / 05期

基金：

中国国家自然科学基金;

关键词：

chemical constituents; mass spectrometry; Shuanghuanglian; traditional Chinese medicine preparations; FLAVONOIDS; COMPONENTS; LIGNANS;

D O I：

10.1002/jssc.202100860

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Shuanghuanglian is a common traditional Chinese medicine prescription. It is an herbal formula composed of Lonicerae Japonicae Flos, Scutellariae Radix, and Forsythiae Fructus. A comprehensive understanding of Shuanghuanglian oral dosage forms components was obtained using a method based on ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry for the separation and characterization of Shuanghuanglian oral liquids, granules, soft capsules, and effervescent tablets. A total of 358 components were chemically defined or tentatively identified, including flavonoids, caffeic acid derivatives, lignans, coumarins, iridoids, triterpenes, and anthraquinones. The results will provide a basis for the general study of Shuanghuanglian and be meaningful for the composition identification of traditional Chinese medicine prescriptions.

引用

页码：1020 / 1030

页数：12

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