New concepts in pathogenesis and treatment of diabetic retinopathy

被引：68
作者：
Spranger, J
Pfeiffer, AFH
机构：
[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Clin Nutr, D-14558 Bergholz Rehbrucke, Germany
[2] Free Univ Berlin, Klinikum Benjamin Franklin, Dept Nutr Endocrinol & Metab, D-12200 Berlin, Germany
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2001年 / 109卷
关键词：
diabetes; retinopathy; angiogenesis; neovascularization; cytokine; growth factor;
D O I：
10.1055/s-2001-18601
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Retinal neovascularization is a major feature of proliferative diabetic retinopathy, which represents a major public health problem, being responsible for more irreversible blindness in persons of middle and older age than any other pathology. The societal burden of ocular neovascularization has prompted extensive research into its mechanisms. The aim of this review will be to briefly summarize the current knowledge regarding the clinical and laboratory findings of diabetic retinopathy. From an investigational view, studies of ocular neovascularization provide important informations, often permitting real-time, serial observations of neovascularization in vivo. This allows investigators to analyse the relevance of specific pathogenic concepts regarding mechanisms of angiogenesis in vivo. This review additionally describe current concepts regarding the pathogenesis and treatment of diabetic retinopathy.
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收藏
页码：S438 / S450
页数：13
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