Alteration of Interferon-α/β Receptors in Chronic Hepatitis B Patients

被引：9

作者：

Meng, Fanli ^{[1
]}

Wang, Jiefei ^{[2
]}

Ge, Jian ^{[1
]}

Fan, Xiaopeng ^{[1
]}

Wang, Bing ^{[1
]}

Han, Liyan ^{[1
]}

Kisseleva, Tatiana ^{[3
]}

Paik, YongHan ^{[3
]}

Brenner, David A. ^{[3
]}

Wang, Kai ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Hepatol, Jinan 250012, Peoples R China

[2] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Hepatol, Shanghai 201508, Peoples R China

[3] Univ Calif San Diego, Dept Med, Sch Med, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2011年 / 31卷 / 03期

关键词：

Interferon-alpha/beta receptor; chronic hepatitis B; interferon-alpha; peripheral blood mononuclear cells (PBMCs); EXPRESSION; CELLS; THERAPY; LIVER; PCR; DNA;

D O I：

10.1007/s10875-011-9518-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background The present study determined type I interferon (IFN) receptor (interferon-alpha/beta receptor (IFNAR)) and its predicable role in interferon-alpha 2b treatment in chronic hepatitis B (CHB) patients. Methods Expression of IFN-alpha/beta R-1 and IFN-alpha/beta R-2 in peripheral blood mononuclear cells and in liver tissue was measured by flow cytometry, immunofluorescence, immunohistochemistry and RT-PCR. Results IFN-alpha/beta R-1 and IFN-alpha/beta R-2 in monocytes and lymphocytes increased in CHB patients. Expression of IFNAR-1 and IFNAR-2 in liver had positive correlation with HBV-DNA in liver tissue. Expression of IFN-alpha/beta R in lymphocytes and monocytes increased in the first month, but then decreased during the subsequent interferon-alpha 2b treatment, patients who had higher levels of IFN-alpha/beta R-2 in monocytes prior to therapy showed better viral response than those with lower levels. Conclusions Expression of IFN-alpha/beta R-2 in monocytes can be used as a predictable parameter to evaluate the effect of IFN-alpha treatment in CHB patients.

引用

页码：521 / 532

页数：12

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