3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration

被引：202

作者：

Feng, Chun ^{[1
,2
]}

Zhang, Wenjie ^{[3
]}

Deng, Cuijun ^{[1
,2
]}

Li, Guanglong ^{[3
]}

Chang, Jiang ^{[1
]}

Zhang, Zhiyuan ^{[4
]}

Jiang, Xinquan ^{[3
]}

Wu, Chengtie ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Prosthodont, Oral Bioengn & Regenerat Med Lab, Shanghai Key Lab Stomatol,Peoples Hosp 9,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[4] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Oral & Maxillofacial Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

来源：

ADVANCED SCIENCE | 2017年 / 4卷 / 12期

基金：

中国国家自然科学基金;

关键词：

biomimetic materials; cell delivery; lotus root-like biomaterials; tissue regeneration; IN-VITRO; BIOMATERIAL SCAFFOLDS; POROUS SCAFFOLDS; HYBRID MATERIALS; AKERMANITE; CERAMICS; DESIGN; ANGIOGENESIS; OSTEOGENESIS; ARCHITECTURE;

D O I：

10.1002/advs.201700401

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature. In recent years, 3D printing scaffolds are major materials for large bone defect repair. However, these traditional 3D scaffolds have low porosity and nonchannel structure, which impede angiogenesis and osteogenesis. In this study, inspired by the microstructure of natural plant lotus root, biomimetic materials with lotus root-like structures are successfully prepared via a modified 3D printing strategy. Compared with traditional 3D materials, these biomimetic materials can significantly improve in vitro cell attachment and proliferation as well as promote in vivo osteogenesis, indicating potential application for cell delivery and bone regeneration.

引用

页数：9

共 45 条

[1] Biological and Biomimetic Materials [J].