Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease

被引：45
作者：
Zhou, Xinyi [1 ]
Jin, Nan [1 ]
Wang, Fei [1 ]
Chen, Baoan [1 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Med Sch, Dept Hematol & Oncol,Key Dept Jiangsu Med, Dingjiagiao 87, Nanjing 210009, Jiangsu, Peoples R China
来源：
CANCER CELL INTERNATIONAL | 2020年 / 20卷 / 01期
关键词：
Allogeneic hematopoietic stem cell transplantation (allo-HSCT); Graft-versus-host disease (GVHD); Mesenchymal stem cells (MSCs); Immunoregulatory function; MSC-derived extracellular vesicles (EVs); REGULATORY T-CELLS; STROMAL CELLS; ACUTE GVHD; IMMUNOSUPPRESSIVE PROPERTIES; RISK-FACTORS; MARROW; TRANSPLANTATION; HYPOXIA; ATTENUATE; INFUSION;
D O I：
10.1186/s12935-020-01193-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is well acknowledged that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for numerous malignant blood diseases, which has also been applied to autoimmune diseases for more than a decade. Whereas graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) as a common serious complication, seriously affecting the efficacy of transplantation. Mesenchymal stem cells (MSCs) derived from a wealth of sources can easily isolate and expand with low immunogenicity. MSCs also have paracrine and immune regulatory functions, leading to a broad application prospect in treatment and tissue engineering. This review focuses on immunoregulatory function of MSCs, factors affecting mesenchymal stem cells to exert immunosuppressive effects, clinical application of MSCs in GVHD and researches on MSC-derived extracellular vesicles (EVs). The latest research progress on MSC in related fields is reviewed as well. The relevant literature from PubMed databases is reviewed in this article.
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页数：11
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