Novel method of preparing hydroxyapatite foams

被引:15
作者
Muthutantri, Anushini [1 ]
Huang, Jie [1 ]
Edirisinghe, Mohan [1 ]
机构
[1] UCL, Dept Mech Engn, London WC1E 7JE, England
关键词
D O I
10.1007/s10856-008-3379-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Porous scaffolds are considered a key strategy in the concept of bone tissue engineering. Hydroxyapatite, which is a bioceramic has been used as a popular scaffold material due to its bioactive and osteoconductive properties. A combination of slurry-dipping and electrospraying has been used as a new foam fabrication method to produce porous and interconnected foam structures. The combined method has shown to overcome the shortcomings of the individual methods and it has produced open pores in the desired range of 100-350 mu m. The porosity which was determined by calculation and microtomography was between 84% and 88%. Reduced cracks and thicker struts were observed in the microstructure, pointing to improved mechanical properties.
引用
收藏
页码:1485 / 1490
页数:6
相关论文
共 22 条
[1]  
Abdullah Y, 2002, KEY ENG MATER, V206-2, P1543
[2]   Biomaterial developments for bone tissue engineering [J].
Burg, KJL ;
Porter, S ;
Kellam, JF .
BIOMATERIALS, 2000, 21 (23) :2347-2359
[3]   Improved mechanical reliability of bone tissue engineering (Zirconia) scaffolds by electrospraying [J].
Chen, QZ ;
Boccaccini, AR ;
Zhang, HB ;
Wang, DZ ;
Edirisinghe, MJ .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2006, 89 (05) :1534-1539
[4]  
Du C, 1999, J BIOMED MATER RES, V44, P407, DOI 10.1002/(SICI)1097-4636(19990315)44:4<407::AID-JBM6>3.0.CO
[5]  
2-T
[6]   Current and droplet size in the electrospraying of liquids. Scaling laws [J].
Ganan-Calvo, AM ;
Davila, J ;
Barrero, A .
JOURNAL OF AEROSOL SCIENCE, 1997, 28 (02) :249-275
[7]  
Gibson L.J., 1997, Cambridge Solid State Science Series, V2e, P15, DOI [10.1017/CBO9781139878326.004, DOI 10.1017/CBO9781139878326.004]
[8]   A REVIEW OF LIQUID ATOMIZATION BY ELECTRICAL MEANS [J].
GRACE, JM ;
MARIJNISSEN, JCM .
JOURNAL OF AEROSOL SCIENCE, 1994, 25 (06) :1005-1019
[9]   Stimulation of bone repair by gene activating glasses [J].
Hench, LL .
BIOCERAMICS 16, 2004, 254-2 :3-6
[10]   BIOCERAMICS - FROM CONCEPT TO CLINIC [J].
HENCH, LL .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 1991, 74 (07) :1487-1510