Susceptibility of bovine mesenchymal stem cells to bovine herpesvirus 4

被引：12
作者：
Donofrio, G
Colleoni, S
Galli, C
Lazzari, G
Cavirani, S
Flammini, CF
机构：
[1] Fac Vet Med, Dipartimento Salute Anim, Sez Malattie Infett Anim, I-43100 Parma, Italy
[2] CIZ Srl, Lab Tecnol Riproduz, I-26100 Cremona, Italy
来源：
JOURNAL OF VIROLOGICAL METHODS | 2005年 / 127卷 / 02期
关键词：
bovine; bovine herpesvirus; mesenchymal stem cells; bone marrow;
D O I：
10.1016/j.jviromet.2005.02.019
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Bovine herpesvirus 4 (BoHV-4) is a gamma herpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbour persistent BoHV-4. Since mesenchymal stem cells in bone marrow regulate the differentiation and proliferation of adjacent haematopoietic precursors, such as macrophages, the interaction between BoHV-4 and mesenchymal stem cells was investigated. Primary bovine mesenchymal stem cells were highly permissive to support full replication of BoHV-4. This finding could be considered a new important step in studies on the potential pathogenesis related to BoHV-4. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：168 / 170
页数：3
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