Evaluation of a transparent cranial implant as a permanent window for cerebral blood flow imaging

被引：14

作者：

Davoodzadeh, Nami ^{[1
]}

Cano-Velazquez, Mildred S. ^{[2
]}

Halaney, David L. ^{[1
]}

Jonak, Carrie R. ^{[3
]}

Binder, Devin K. ^{[3
]}

Aguilar, Guillermo ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA

[2] Univ Nacl Autonoma Mexico, Inst Invest Mat, Mexico City, DF, Mexico

[3] Univ Calif Riverside, Div Biomed Sci, Sch Med, Riverside, CA 92521 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 10期

基金：

美国国家科学基金会;

关键词：

YTTRIA-STABILIZED-ZIRCONIA; LASER SPECKLE CONTRAST; RESOLUTION; MICROCIRCULATION; BRAIN; TOMOGRAPHY; VELOCITY; DISEASE; TISSUE; SKULL;

D O I：

10.1364/BOE.9.004879

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Laser speckle imaging (LSI) of mouse cerebral blood flow was compared through a transparent nanocrystalline yttria-stabilized zirconia (nc-YSZ) cranial implant over time (at days 0, 14, and 28, n = 3 mice), and vs. LSI through native skull (at day 60, n = 1 mouse). The average sharpness of imaged vessels was found to remain stable, with relative change in sharpness under 7.69% +/- 1.2% over 28 days. Through-implant images of vessels at day 60 appeared sharper and smaller on average, with microvessels clearly visible, compared to through-skull images where vessels appeared blurred and distorted. These results suggest that long-term imaging through this implant is feasible. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：4879 / 4892

页数：14

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