Synthesis of α-ketoamides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

被引：106

作者：

Grassot, Jean-Marie ^{[1
]}

Masson, Geraldine ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, ICSN, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 05期

关键词：

isocyanides; ketoamides; multicomponent reactions; nitrones; Ugi reaction;

D O I：

10.1002/anie.200704840

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A twist in the Ugi four-component reaction: The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-Å molecular sieves afforded α-ketoamides in moderate to good yields (see scheme). In contrast, 3-Å molecular sieves did not promote the desired multicomponent reaction. R1 = alkyl; R2 = alkyl, aryl. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：947 / 950

页数：4

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