Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives

被引：3

作者：

Vasil'ev, L. S. ^{[1
]}

Baranin, S. V. ^{[1
]}

Ignatenko, A. V. ^{[1
]}

Nelyubina, Yu. V. ^{[2
]}

Dorokhov, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 07期

关键词：

4-alkoxy-1,4-dihydropyrido[4,3-d]pyrimidines; 4-hydroxy-1,4-dihydropyrido[4,3-d]pyrimidine; pyrido[4,3-d]pyrimidines; 4-trifluoromethyl-substituted heterocycles; FLUORINE; TRIFLUOROMETHYL; CHEMISTRY;

D O I：

10.1007/s11172-010-0254-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Earlier unknown 4-alkoxy- and 4-hydroxy-5-methyl-4-trifluoromethyl-1,4-dihydropyrido[4,3-d]pyrimidines were obtained by the reaction of 5-acetyl-4-dimethylaminovinyl-6-(trifluoromethyl)pyrimidine with alcoholic (aqueous) solutions of NH3. The former eliminate alcohol (water) on sublimation in vacuo to be converted to 5-methyl-4-(trifluoromethyl)-pyrido[4,3-d]pyrimidine. The latter upon the action of alcohols (water) under mild conditions were reverted to the corresponding 4-alkoxy-and 4-hydroxydihydropyrido[4,3-d]pyrimidines.

引用

页码：1403 / 1407

页数：5

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