An Efficient Titanium Catalyst for Enantioselective Cyanation of Aldehydes: Cooperative Catalysis

被引：114

作者：

Zhang, Zhipeng ^{[1
]}

Wang, Zheng ^{[1
]}

Zhang, Ruzhou ^{[1
]}

Ding, Kuiling ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 38期

关键词：

aldehydes; asymmetric catalysis; cyanides; synthetic methods; titanium; CHIRAL (SALEN)TITANIUM COMPLEXES; ASYMMETRIC CYANOHYDRIN SYNTHESIS; RING-OPENING REACTIONS; TRIMETHYLSILYL CYANIDE; SALEN COMPLEXES; BENZALDEHYDE; ACIDS;

D O I：

10.1002/anie.201002127

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Two-in-one: The integration of two salen/ Ti=O units into one molecule allows the enantioselective cyanation of aldehydes to afford the enantioenriched natural or nonnatural cyanohydrin derivatives with turnover numbers of 1960-172000 and ee values up to 97% (see scheme). Some of the cyanohydrin derivatives are key intermediates for the synthesis of chiral pharmaceuticals or agrochemicals. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6746 / 6750

页数：5

共 40 条

[1] Synthetic and mechanistic studies on asymmetric cyanohydrin synthesis using a titanium(salen) bimetallic catalyst [J].