Conventional or threshold-hunting TMS? A tale of two SICIs

被引:19
作者
Cirillo, John [1 ,2 ]
Semmler, John G. [3 ]
Mooney, Ronan A. [1 ,2 ]
Byblow, Winston D. [1 ,2 ]
机构
[1] Univ Auckland, Dept Exercise Sci, Private Bag 92019, Auckland 1142, New Zealand
[2] Univ Auckland, Ctr Brain Res, Auckland, New Zealand
[3] Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia
关键词
Transcranial magnetic stimulation; Short-interval intracortical inhibition; Adaptive threshold-hunting; Current direction; Interstimulus interval; TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; INTERVAL INTRACORTICAL INHIBITION; VENTRAL PREMOTOR CORTEX; CORTICOSPINAL NEURONS; INDIRECT ACTIVATION; CURRENT DIRECTION; SURFACE EMG; FACILITATION; EXCITABILITY;
D O I
10.1016/j.brs.2018.07.047
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: In human primary motor cortex (M1), the paired-pulse transcranial magnetic stimulation (TMS) paradigm of short-interval intracortical inhibition (SICI) can be expressed conventionally as a percent change in the relative amplitude of a conditioned motor evoked potential to non-conditioned; or adaptive threshold-hunting a target motor evoked potential amplitude in the absence or presence of a conditioning stimulus, and noting the relative change in stimulation intensity. The suitability of each approach may depend on the induced current direction, which probe separate M1 interneuronal populations. Objective: To examine the influence of conditioning stimulus intensity, interstimulus interval (ISI) and current direction for adaptive threshold-hunting and conventional SICI using equivalent TMS intensities. Methods: In 16 participants (21-32 years), SICI was examined using adaptive threshold-hunting and conventional paired-pulse TMS with posterior-anterior and anterior-posterior stimulation, ISIs of 2 and 3 ms, and a range of conditioning intensities. Results: Inhibition with adaptive threshold-hunting was greater for anterior-posterior stimulation with an ISI of 3 ms (23.6 +/- 9.0%) compared with 2 ms (7.5 +/- 7.8%, P < 0.001) and posterior-anterior stimulation at both ISIs (2 ms 8.6 +/- 8.7%, 3 ms 5.9 +/- 4.8%; P < 0.001). There was an association between inhibition obtained with conventional and adaptive threshold-hunting for posterior-anterior but not anterior-posterior stimulation (2 ms only, r = 0.68, P = 0.03). Conclusions: More inhibition was evident with anterior-posterior than posterior-anterior current for both adaptive threshold-hunting and conventional paired-pulse TMS. Assessment of SICI with anteriorposterior stimulation was not directly comparable between the two approaches. However, the amount of inhibition was dependent on conditioning stimulus intensity and ISI for both SICI techniques. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:1296 / 1305
页数:10
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