共 31 条
Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro
被引:11
作者:

Chen, Yu
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机构:
Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Chen, Kun
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Nanjing Univ Chinese Med, Dept Endocrinol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Zhou, Yuan
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Nanjing Univ Chinese Med, Sch Med & Life Sci, Nanjing 210023, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Li, Xingjia
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Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Mao, Xiaodong
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Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Wei, Xiao
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Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Xu, Yijiao
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Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Yang, Wanwei
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Nanjing Univ Chinese Med, Clin Lab, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Chen, Guofang
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h-index: 0
机构:
Nanjing Univ Chinese Med, Dept Endocrinol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China

Liu, Chao
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h-index: 0
机构:
Nanjing Univ Chinese Med, Dept Endocrinol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China
机构:
[1] Nanjing Univ Chinese Med, Res Ctr Endocrinol & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Dept Endocrinol, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China
[3] Nanjing Univ Chinese Med, Sch Med & Life Sci, Nanjing 210023, Jiangsu, Peoples R China
[4] Nanjing Univ Chinese Med, Clin Lab, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Jiangsu, Peoples R China
基金:
中国国家自然科学基金;
关键词:
Microcystin-LR;
Glucose metabolism;
beta-Cell function;
Oatp;
Apoptosis;
AIR-POLLUTION;
APOPTOSIS;
IDENTIFICATION;
DYSFUNCTION;
PHALLOIDIN;
TOXICITY;
PATHWAYS;
D O I:
10.1016/j.toxlet.2020.03.003
中图分类号:
R99 [毒物学(毒理学)];
学科分类号:
100405 ;
摘要:
This study aimed to investigate the toxic effects of microcystin-LR (MC-LR), which is released from several bloom-forming cyanobacteria, on the glucose metabolism of pancreatic beta cells in vivo and in vitro. Male mice and the pancreatic MIN6 cells were respectively treated with varying concentrations of MC-LR. After 3- or 6-months of MC-LR exposure, increase in the body weight of mice was found to be inhibited, and the structure of their pancreatic tissues was damaged with impaired glucose tolerance and impaired insulin secretion. Further, these toxic effects became more pronounced with time and with increased dosages. Direct cytotoxic effects of MC-LR were observed in the MIN6 pancreatic beta-cells possibly due to their expression of the MC-LR specific transporter. MC-LR entered the MIN6 cells that significantly reduced the cell viability. Both in vivo and in vitro experiments demonstrated that MC-LR was able to induce apoptosis, possibly associated with mitochondrial damage. Above all, these findings implied that MC-LR may be transported into the pancreatic beta cells and cause subsequent cytotoxicity.
引用
收藏
页码:106 / 113
页数:8
相关论文
共 31 条
[21]
Identification of ATP-synthase as a novel intracellular target for microcystin-LR
[J].
Mikhailov, A
;
Härmälä-Braskén, AS
;
Hellman, J
;
Meriluoto, J
;
Eriksson, JE
.
CHEMICO-BIOLOGICAL INTERACTIONS,
2003, 142 (03)
:223-237

Mikhailov, A
论文数: 0 引用数: 0
h-index: 0
机构: Turku Ctr Biotechnol, FIN-20521 Turku, Finland

Härmälä-Braskén, AS
论文数: 0 引用数: 0
h-index: 0
机构: Turku Ctr Biotechnol, FIN-20521 Turku, Finland

Hellman, J
论文数: 0 引用数: 0
h-index: 0
机构: Turku Ctr Biotechnol, FIN-20521 Turku, Finland

Meriluoto, J
论文数: 0 引用数: 0
h-index: 0
机构: Turku Ctr Biotechnol, FIN-20521 Turku, Finland

Eriksson, JE
论文数: 0 引用数: 0
h-index: 0
机构: Turku Ctr Biotechnol, FIN-20521 Turku, Finland
[22]
Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells
[J].
Monks, Noel R.
;
Liu, Shuqian
;
Xu, Yongsheng
;
Yu, Hui
;
Bendelow, Adam S.
;
Moscow, Jeffrey A.
.
MOLECULAR CANCER THERAPEUTICS,
2007, 6 (02)
:587-598

Monks, Noel R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA

Liu, Shuqian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA

Xu, Yongsheng
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA

Yu, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA

Bendelow, Adam S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA

Moscow, Jeffrey A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA Univ Kentucky, Dept Pediat, Lexington, KY 40502 USA
[23]
Air Pollution and Type 2 Diabetes Mechanistic Insights
[J].
Rajagopalan, Sanjay
;
Brook, Robert D.
.
DIABETES,
2012, 61 (12)
:3037-3045

Rajagopalan, Sanjay
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

Brook, Robert D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA
[24]
OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide
[J].
Schwabedissen, Henriette E. Meyer Zu
;
Boettcher, Kerstin
;
Steiner, Tobias
;
Schwarz, Ute I.
;
Keiser, Markus
;
Kroemer, Heyo K.
;
Siegmund, Werner
.
DIABETES,
2014, 63 (02)
:775-784

Schwabedissen, Henriette E. Meyer Zu
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland
Univ Med Greifswald, Dept Pharmacol, Ctr Drug Absorpt & Transport, Greifswald, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Boettcher, Kerstin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Greifswald, Dept Pharmacol, Ctr Drug Absorpt & Transport, Greifswald, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Steiner, Tobias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Greifswald, Dept Pharmacol, Ctr Drug Absorpt & Transport, Greifswald, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Schwarz, Ute I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Clin Pharmacol, London, ON, Canada Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Keiser, Markus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Gottingen, Fac Med, D-37073 Gottingen, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Kroemer, Heyo K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Greifswald, Dept Clin Pharmacol, Ctr Drug Absorpt & Transport, Greifswald, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland

Siegmund, Werner
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Gottingen, Fac Med, D-37073 Gottingen, Germany Univ Basel, Dept Pharmaceut Sci, Basel, Switzerland
[25]
Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean?
[J].
Vareli, Katerina
;
Jaeger, Walter
;
Touka, Anastasia
;
Frillingos, Stathis
;
Briasoulis, Evangelos
;
Sainis, Ioannis
.
MARINE DRUGS,
2013, 11 (08)
:2751-2768

Vareli, Katerina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece
Univ Ioannina, Human Canc Biobank Ctr, Intersci Mol Oncol Lab, GR-45110 Ioannina, Greece Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece

Jaeger, Walter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Clin Pharm & Diagnost, A-1090 Vienna, Austria Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece

Touka, Anastasia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Human Canc Biobank Ctr, Intersci Mol Oncol Lab, GR-45110 Ioannina, Greece Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece

Frillingos, Stathis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Biol Chem Lab, Sch Med, GR-45110 Ioannina, Greece Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece

Briasoulis, Evangelos
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Human Canc Biobank Ctr, Intersci Mol Oncol Lab, GR-45110 Ioannina, Greece Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece

Sainis, Ioannis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Human Canc Biobank Ctr, Intersci Mol Oncol Lab, GR-45110 Ioannina, Greece Univ Ioannina, Dept Biol Applicat & Technol, GR-45110 Ioannina, Greece
[26]
Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway
[J].
Wang, Qilong
;
Liu, Yuanli
;
Guo, Jingsong
;
Lin, Song
;
Wang, Yeqi
;
Yin, Tieying
;
Gregersen, Hans
;
Hu, Tingzhang
;
Wang, Guixue
.
CHEMOSPHERE,
2019, 218
:438-448

Wang, Qilong
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Liu, Yuanli
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Guo, Jingsong
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Three Gorges Reservoirs Ecoenvironm, MOE, Chongqing 400045, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Lin, Song
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Wang, Yeqi
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Yin, Tieying
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Gregersen, Hans
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Hu, Tingzhang
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China

Wang, Guixue
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants Chongq, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China
[27]
Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish
[J].
Wang, Zhikuan
;
Li, Guangyu
;
Wu, Qin
;
Liu, Chunsheng
;
Shen, JianZhong
;
Yan, Wei
.
CHEMOSPHERE,
2019, 214
:598-605

Wang, Zhikuan
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

Li, Guangyu
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

Wu, Qin
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

Liu, Chunsheng
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

Shen, JianZhong
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

Yan, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Hubei Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Wuhan 430064, Hubei, Peoples R China Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China
[28]
Persistent Organic Pollutants and Type 2 Diabetes: A Prospective Analysis in the Nurses' Health Study and Meta-analysis
[J].
Wu, Hongyu
;
Bertrand, Kimberly A.
;
Choi, Anna L.
;
Hu, Frank B.
;
Laden, Francine
;
Grandjean, Philippe
;
Sun, Qi
.
ENVIRONMENTAL HEALTH PERSPECTIVES,
2013, 121 (02)
:153-161

Wu, Hongyu
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Bertrand, Kimberly A.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Choi, Anna L.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Hu, Frank B.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Laden, Francine
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA USA
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Grandjean, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
Univ So Denmark, Inst Publ Hlth, Odense, Denmark Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Sun, Qi
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[29]
Microcystis bloom containing microcystin-LR induces type 2 diabetes mellitus
[J].
Zhang, Qiong
;
Qin, Wendi
;
Yang, Liuyan
;
An, Jing
;
Zhang, Xuxiang
;
Hong, Hao
;
Xu, Lizhi
;
Wang, Yaping
.
TOXICOLOGY LETTERS,
2018, 294
:87-94

Zhang, Qiong
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China
Univ Oxford, Dept Earth Sci, Oxford OX1 3AN, England Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Qin, Wendi
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Yang, Liuyan
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

An, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Zhang, Xuxiang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Hong, Hao
论文数: 0 引用数: 0
h-index: 0
机构:
China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Xu, Lizhi
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h-index: 0
机构:
Nanjing Univ, Sch Med, Jiangsu Key Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

Wang, Yaping
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Nanjing Univ, Sch Med, Jiangsu Key Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China
[30]
Microcystin-LR induces dysfunction of insulin secretion in rat insulinoma (INS-1) cells: Implications for diabetes mellitus
[J].
Zhao, Yanyan
;
Shi, Kun
;
Su, Xiaomei
;
Xie, Liqiang
;
Yan, Yunjun
.
JOURNAL OF HAZARDOUS MATERIALS,
2016, 314
:11-21

Zhao, Yanyan
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Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China

Shi, Kun
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Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China

Su, Xiaomei
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机构:
Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China

Xie, Liqiang
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机构:
Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China

Yan, Yunjun
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机构:
Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Key Lab Mol Biophys, Minist Educ, 1037 Luoyu Rd, Wuhan 430074, Peoples R China Chinese Acad Sci, Nanjing Inst Geog & Limnol, State Key Lab Lake Sci & Environm, 73 East Beijing Rd, Nanjing 210008, Jiangsu, Peoples R China