On the architecture of translational research designed to control chronic lymphocytic leukemia

被引：11

作者：

Hallek, Michael ^{[1
]}

机构：

[1] Univ Cologne, Dept Internal Med 1, Cologne, Germany

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2018年

关键词：

MINIMAL RESIDUAL DISEASE; FLUDARABINE PLUS CYCLOPHOSPHAMIDE; INTERNATIONAL PROGNOSTIC INDEX; PREVIOUSLY UNTREATED PATIENTS; CELL ANTIGEN RECEPTOR; PHASE-III TRIAL; LRF CLL4 TRIAL; INITIAL THERAPY; OPEN-LABEL; INDEPENDENT PREDICTOR;

D O I：

10.1182/asheducation-2018.1.1

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Chronic lymphocytic leukemia (CLL) has been 1 of the most dynamic fields of clinical research over the last 2 decades. Important advances in understanding the biology of CLL have led to the development of new prognostic and diagnostic tools. Concurrently, several recently approved new agents hold the potential to fundamentally change the management of this leukemia and have started to improve clinical outcomes for patients. This conceptual review summarizes the major recent insights regarding the biology of CLL, the technological advances that have allowed refinement of the prognostication of the clinical course, and the new therapeutic strategies that are currently under investigation to further ameliorate the outcome for patients with CLL.

引用

页码：1 / 8

页数：8

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