The evolutionary origins of the cat attractant nepetalactone in catnip

被引：89

作者：

Lichman, Benjamin R. ^{[1
]}

Godden, Grant T. ^{[2
]}

Hamilton, John P. ^{[3
]}

Palmer, Lira ^{[4
]}

Kamileen, Mohamed O. ^{[4
]}

Zhao, Dongyan ^{[3
,11
]}

Vaillancourt, Brieanne ^{[3
]}

Wood, Joshua C. ^{[3
]}

Sun, Miao ^{[2
]}

Kinser, Taliesin J. ^{[2
,5
]}

Henry, Laura K. ^{[6
]}

Rodriguez-Lopez, Carlos ^{[4
]}

Dudareva, Natalia ^{[6
,7
,8
]}

Soltis, Douglas E. ^{[2
,5
]}

Soltis, Pamela S. ^{[2
]}

Buell, C. Robin ^{[3
,9
,10
]}

O'Connor, Sarah E. ^{[4
]}

机构：

[1] Univ York, Ctr Novel Agr Prod, Dept Biol, York YO10 5DD, N Yorkshire, England

[2] Univ Florida, Florida Museum Nat Hist, Gainesville, FL 32611 USA

[3] Michigan State Univ, Dept Plant Biol, 612 Wilson Rd, E Lansing, MI 48824 USA

[4] Max Planck Inst Chem Ecol, Dept Nat Prod Biosynth, D-07745 Jena, Germany

[5] Univ Florida, Dept Biol, Gainesville, FL 32611 USA

[6] Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA

[7] Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47907 USA

[8] Purdue Univ, Purdue Ctr Plant Biol, W Lafayette, IN 47907 USA

[9] Michigan State Univ, Plant Resilience Inst, 612 Wilson Rd, E Lansing, MI 48824 USA

[10] Michigan State Univ, MSU AgBioRes, 446 West Circle Dr, E Lansing, MI 48824 USA

[11] Cornell Univ, Inst Biotechnol, 525 Tower Rd, Ithaca, NY 14853 USA

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 20期

基金：

英国科研创新办公室; 美国国家科学基金会;

关键词：

PHYLOGENETIC ANALYSIS; PENALIZED LIKELIHOOD; SEQUENCE ALIGNMENT; GENOME SEQUENCE; WEB SERVER; GENE; BIOSYNTHESIS; TOOL; RNA; IDENTIFICATION;

D O I：

10.1126/sciadv.aba0721

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Catnip or catmint (Nepeta spp.) is a flowering plant in the mint family (Lamiaceae) famed for its ability to attract cats. This phenomenon is caused by the compound nepetalactone, a volatile iridoid that also repels insects. Iridoids are present in many Lamiaceae species but were lost in the ancestor of the Nepetoideae, the subfamily containing Nepeta. Using comparative genomics, ancestral sequence reconstructions, and phylogenetic analyses, we probed the re-emergence of iridoid biosynthesis in Nepeta. The results of these investigations revealed mechanisms for the loss and subsequent re-evolution of iridoid biosynthesis in the Nepeta lineage. We present evidence for a chronology of events that led to the formation of nepetalactone biosynthesis and its metabolic gene cluster. This study provides insights into the interplay between enzyme and genome evolution in the origins, loss, and re-emergence of plant chemical diversity.

引用

页数：14

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