Reactive Oxygen Species, Granulocytes, and NETosis

被引：44

作者：

Arazna, Magdalena ^{[1
]}

Pruchniak, Michal P. ^{[1
]}

Demkow, Urszula ^{[1
]}

机构：

[1] Dept Lab Diagnost & Clin Immunol Dev Age, PL-00576 Warsaw, Poland

来源：

RESPIRATORY VIROLOGY AND IMMUNOGENICITY | 2015年 / 836卷

关键词：

Free radicals; Myeloperoxidase; NADPH oxidase; Neutrophil extracellular traps; Reactive oxygen species; NEUTROPHIL EXTRACELLULAR TRAP; MYELOPEROXIDASE; RELEASE; LIFE;

D O I：

10.1007/5584_2014_12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When pathogens invade the body, neutrophils create the first line of defense. Basic weaponry consists of phagocytosis and degranulation, but these cells have yet another ace in the sleeve, a unique strategy in which invading microorganisms are being destroyed. These cellular warriors are able to release nuclear chromatin and form extracellular structure, known as neutrophil extracellular traps (NET). NET formation is connected with the presence of free radicals. Research has shown that inhibition of free radical formation leads to suppression of NET release. The exact mechanisms controlling cooperation of free radicals with NET still remain unclear. New investigations in this field may contribute to discovery of NET etiology and put a new light on related disorders.

引用

页码：1 / 7

页数：7

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