Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

被引：98

作者：

Chua, Gilbert T. ^{[1
,2
]}

Kwan, Mike Yat Wah ^{[3
]}

Chui, Celine S. L. ^{[4
,5
,6
]}

Smith, Robert David ^{[4
]}

Cheung, Edmund Chi-Lok ^{[7
]}

Tian, Tian ^{[6
]}

Leung, Miriam T. Y. ^{[6
,7
]}

Tsao, Sabrina Siu Ling ^{[1
,2
]}

Kan, Elaine ^{[8
]}

Ng, Wing Kei Carol ^{[8
]}

Chan, Victor Chi Man ^{[9
]}

Tai, Shuk Mui ^{[9
]}

Yu, Tak Ching ^{[9
]}

Lee, Kwok Piu ^{[9
]}

Wong, Joshua Sung Chih ^{[3
]}

Lin, Ying Kit ^{[3
]}

Shek, Chi Chiu ^{[3
]}

Leung, Agnes Sze Yin ^{[10
]}

Chow, Chit Kwong ^{[11
]}

Li, Ka Wah ^{[12
]}

Ma, Johnny ^{[13
,14
,15
,16
]}

Fung, Wai Yuk ^{[13
,14
,15
,16
]}

Lee, Daniel ^{[17
]}

Ng, Ming Yen ^{[18
,19
]}

Wong, Wilfred Hing Sang ^{[1
]}

Tsang, Hing Wai ^{[1
]}

Kwok, Janette ^{[20
]}

Leung, Daniel ^{[1
]}

Chung, Kin Lai ^{[21
]}

Chow, Chun Bong ^{[1
]}

Chan, Godfrey Chi Fung ^{[1
,2
]}

Leung, Wing Hang ^{[1
,2
]}

To, Kelvin Kai Wang ^{[22
]}

Yuen, Kwok Yung ^{[22
]}

Lau, Yu Lung ^{[1
,2
]}

Wong, Ian Chi Kei ^{[6
,7
,23
]}

Ip, Patrick ^{[1
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[2] Hong Kong Childrens Hosp, Dept Paediat, Hong Kong, Peoples R China

[3] Princess Margaret Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[4] Univ Hong Kong, Sch Nursing, Hong Kong, Peoples R China

[5] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China

[6] Hong Kong Sci & Technol Pk, Lab Data Discovery Hlth D24H, Hong Kong, Peoples R China

[7] Univ Hong Kong, Ctr Safe Medicat Practice & Res, Dept Pharmacol & Pharm, Hong Kong, Peoples R China

[8] Hong Kong Childrens Hosp, Dept Radiol, Hong Kong, Peoples R China

[9] Pamela Youde Nethersole Eastern Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[10] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Pediat, Hong Kong, Peoples R China

[11] United Christian Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[12] Tuen Mun Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China

[13] Caritas Med Ctr, Dept Radiol, Hong Kong, Peoples R China

[14] North Landau Hosp, Dept Radiol, Hong Kong, Peoples R China

[15] Princess Margaret Hosp, Dept Radiol, Hong Kong, Peoples R China

[16] Yan Chai Hosp, Dept Radiol, Hong Kong, Peoples R China

[17] Pamela Youde Nethersole Eastern Hosp, Dept Radiol, Hong Kong, Peoples R China

[18] Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Peoples R China

[19] Univ Hong Kong, Dept Med Imaging, Shenzhen Hosp, Hong Kong, Peoples R China

[20] Queen Mary Hosp, Dept Pathol, Div Transplantat & Immunogenet, Hong Kong, Peoples R China

[21] Hosp Author Head Off, Qual & Safety Div, Hong Kong, Peoples R China

[22] Univ Hong Kong, Li Ka Shing Fac Med, Carol Yu Ctr Infect, Dept Microbiol, Hong Kong, Peoples R China

[23] UCL, UCL Sch Pharm, Res Dept Practice & Policy, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 04期

关键词：

myocarditis; pericarditis; adolescents; Comirnaty; Hong Kong;

D O I：

10.1093/cid/ciab989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. Methods This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. Results Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. Conclusions There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose. There is an increased risk of acute myocarditis/pericarditis in adolescent males following Comirnaty vaccination, especially following the second dose, providing the direct evidence to support the change in recommending Hong Kong's adolescents to receive one dose of the Comirnaty vaccine.

引用

页码：673 / 681

页数：9

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