Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone: A randomized controlled trial

被引：43

作者：

Cho, Sung Joon ^{[1
]}

Yook, Keunyoung ^{[1
]}

Kim, Borah ^{[1
]}

Choi, Tai Kiu ^{[1
]}

Lee, Kang Soo ^{[1
]}

Kim, Yong Woo ^{[1
]}

Lee, Ji Eun ^{[1
]}

Suh, Shin Young ^{[1
]}

Yook, Ki Hwan ^{[1
]}

Lee, Sang-Hyuk ^{[1
]}

机构：

[1] CHA Univ Sch Med, Dept Psychiat, CHA Bundang Med Ctr, Songnam 463712, Kyounggi Do, South Korea

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 01期

关键词：

Cognition; Mirtazapine; Negative symptom; Risperidone; Schizophrenia; ADD-ON MIRTAZAPINE; DOUBLE-BLIND; THERAPY; HALOPERIDOL;

D O I：

10.1016/j.pnpbp.2010.11.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This preliminary study aimed to determine if adding mirtazapine to risperidone might improve negative and cognitive symptoms in schizophrenia. In an 8-week, double-blind clinical trial, we randomly assigned 21 stabilized outpatients with schizophrenia undergoing risperidone treatment to adjunctive treatment with either mirtazapine or a placebo. The mirtazapine group exhibited a statistically significant improvement in cognitive function, including vocabulary and immediate memory, and negative symptoms (as measured by negative symptom scales) and showed an adverse effect of 5.83 kg mean weight gain. This study suggests augmenting risperidone with mirtazapine can effectively improve both negative and some cognitive symptoms of schizophrenia. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：208 / 211

页数：4

共 17 条

[1] The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: A double-blind randomized placebo-controlled trial [J].

Abbasi, Seyed-Hesameddin ;

Behpournia, Haleh ;

Ghoreshi, Aboulfazl ;

Salehi, Bahman ;

Raznahan, Maedeh ;

Rezazadeh, Shams-Ali ;

Rezaei, Farzin ;

Akhondzadeh, Shahin .

SCHIZOPHRENIA RESEARCH, 2010, 116 (2-3) :101-106

[2] THE DIAGNOSIS OF SCHIZOPHRENIA [J].

ANDREASEN, NC .

SCHIZOPHRENIA BULLETIN, 1987, 13 (01) :9-22

[3] Efficacy of mirtazapine add on therapy to haloperidol in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled study [J].

Berk, M ;

Ichim, C ;

Brook, S .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2001, 16 (02) :87-92

[4] Mirtazapine add-on therapy in the treatment of schizophrenia with atypical antipsychotics: a double-blind, randomised, placebo-controlled clinical trial [J].

Berk, Michael ;

Gama, Clarissa S. ;

Sundram, Suresh ;

Hustig, Harry ;

Koopowitz, Les ;

D'Souza, Russell ;

Malloy, Hamish ;

Rowland, Cate ;

Monkhouse, Alison ;

Monkhouse, Andrew ;

Bole, Fiona ;

Sathiyamoorthy, Sumathy ;

Piskulic, Danijela ;

Dodd, Seetal .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2009, 24 (03) :233-238

[5] Add-on mirtazapine enhances effects on cognition in schizophrenic patients under stabilized treatment with clozapine [J].

Delle Chiaie, Roberto ;

Salviati, Massimo ;

Fiorentini, Samantha ;

Biondi, Massimo .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2007, 15 (06) :563-568

[6] RITANSERIN, A SELECTIVE 5-HT(2/1C) ANTAGONIST, AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA - A PLACEBO-CONTROLLED DOUBLE-BLIND TRIAL [J].

DUINKERKE, SJ ;

BOTTER, PA ;

JANSEN, AAI ;

VANDONGEN, PAM ;

VANHAAFTEN, AJ ;

BOOM, AJ ;

VANLAARHOVEN, JHM ;

BUSARD, HLSM .

BRITISH JOURNAL OF PSYCHIATRY, 1993, 163 :451-455

[7] PATIENT ASSESSMENT IN CLINICAL-TRIALS [J].

GUY, W .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1982, 6 (4-6) :601-606

[8]

Hamilton M., 1967, Br J Soc Clin Psychol, V6, P278, DOI 10.1111/j.2044-8260.1967.tb00530.x

[9] Add-on mirtazapine enhances antipsychotic effect of first generation antipsychotics in schizophrenia: A double-blind, randomized, placebo-controlled trial [J].

Joffe, Grigori ;

Terevnikov, Viatcheslav ;

Joffe, Marina ;

Stenberg, Jan-Henry ;

Burkin, Mark ;

Tiihonen, Jari .

SCHIZOPHRENIA RESEARCH, 2009, 108 (1-3) :245-251

[10] THE POSITIVE AND NEGATIVE SYNDROME SCALE (PANSS) FOR SCHIZOPHRENIA [J].

KAY, SR ;

FISZBEIN, A ;

OPLER, LA .

SCHIZOPHRENIA BULLETIN, 1987, 13 (02) :261-276

← 1 2 →