Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics

被引：30

作者：

Adhikari, Archana ^{[1
]}

Asdaq, Syed Mohammed Basheeruddin ^{[2
]}

Al Hawaj, Maitham A. ^{[3
]}

Chakraborty, Manodeep ^{[1
]}

Thapa, Gayatri ^{[1
]}

Bhuyan, Nihar Ranjan ^{[4
]}

Imran, Mohd. ^{[5
]}

Alshammari, Mohammed Kanan ^{[6
]}

Alshehri, Mohammed M. ^{[7
]}

Harshan, Aishah Ali ^{[8
]}

Alanazi, Abeer ^{[9
]}

Alhazmi, Bushra Dhuhayyan ^{[10
]}

Sreeharsha, Nagaraja ^{[11
,12
]}

机构：

[1] Himalayan Pharm Inst Majhitar, Pharmacol Dept, Sikkim 737136, India

[2] AlMaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh 13713, Saudi Arabia

[3] King Faisal Univ, Coll Clin Pharm, Dept Pharm Practice, Al Hufuf 31982, Saudi Arabia

[4] Himalayan Pharm Inst, Dept Pharmaceut Anal, Sikkim 737136, India

[5] Northern Border Univ, Fac Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[6] Rafha Cent Hosp, Dept Pharmaceut Care, Rafha 91911, Saudi Arabia

[7] Minist Natl Guard Hlth Affairs, Pharmaceut Care Dept, Riyadh 11426, Saudi Arabia

[8] King Khalid Mil City Hosp, Northern Area Armed Forces Hosp, Dept Pharmaceut Care, Hafar al Batin 39745, Saudi Arabia

[9] King Fahad Specialist Hosp, Hlth Cluster Eastern Prov 1, Dept Pharmaceut Care, Dammam 32253, Saudi Arabia

[10] Northern Border Univ, Fac Pharm, Rafha 91911, Saudi Arabia

[11] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia

[12] Vidya Siri Coll Pharm, Dept Pharmaceut, Sarjapura Rd, Bengaluru 560035, Karnataka, India

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 10期

关键词：

anticancer drugs; cardiotoxicity; pharmacogenetics; radiation therapy; chemotherapeutic agent; DOXORUBICIN-INDUCED CARDIOTOXICITY; CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY; T-CELL THERAPY; INDUCED CARDIOMYOPATHY; OXIDATIVE STRESS; RADIATION-THERAPY; HEART-FAILURE; CANCER; MECHANISMS; CHEMOTHERAPY;

D O I：

10.3390/ph14100970

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. This article addresses the prevalence of cardiotoxicity mediated by commonly used chemotherapeutic and immunotherapeutic agents. The role of susceptible genes and radiation therapy in the occurrence of cardiotoxicity is also reviewed. This review also emphasizes the protective role of antioxidants and future perspectives in anticancer drug-induced cardiotoxicities.</p>

引用

页数：23

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