In situ grown fibrous composites of poly(DL-lactide) and hydroxyapatite as potential tissue engineering scaffolds

被引：21

作者：

Chen, Jiangang ^{[1
]}

Li, Xiaohong ^{[1
,2
]}

Cui, Wenguo ^{[1
]}

Xie, Chengying ^{[2
]}

Zou, Jie ^{[1
]}

Zou, Bin ^{[2
]}

机构：

[1] SW Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Peoples R China

[2] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

来源：

POLYMER | 2010年 / 51卷 / 26期

基金：

中国国家自然科学基金;

关键词：

In situ grown fibrous composites; Mechanical properties; Tissue engineering scaffold; SINTERED HYDROXYAPATITE; NANOFIBROUS SCAFFOLDS; POLY(ETHYLENE GLYCOL); ELECTROSPUN FIBERS; APATITE FORMATION; MINERALIZATION; KINETICS; WETTABILITY; MONOLAYERS; GELATIN;

D O I：

10.1016/j.polymer.2010.10.050

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In situ grown hydroxyapatite (HA) within electrospun poly(DL-lactide) (PDLLA) fibers were initially investigated as potential tissue engineering scaffolds with respect to the mechanical performances, biomineralization capability, degradation behaviors, cell growth and differentiation profiles. The tensile strength and Young's moduli of in situ grown composites (IGC) were 8.2 +/- 1.1 and 63.5 +/- 5.6 MPa, respectively, which were significantly higher than those of blend electrospun composites (BEC) with 25.2% of HA inoculation. The interactions between HA and matrix polymers were approved by the red-shifts of C=O stretching and OH- stretching modes and the increases in glass transition temperatures of fibrous composites. The localization of apatite phase on the fiber surface improved the biomineralization capability and enhanced the morphological stability of the fibers and fibrous mats even when the degradation of matrix polymers was detected. The cell viability and alkaline phosphatase levels were significantly higher for composites IGC, indicating favorable scaffolds for cell proliferation and osteogenic differentiation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6268 / 6277

页数：10

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