Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes

被引：15
作者：
Tan, Doryn Meam-Yee [1 ,2 ]
Fu, Ju-Yen [1 ]
Wong, Fu-Shun [1 ]
Er, Hui-Meng [2 ]
Chen, Yu-Sui [3 ]
Nesaretnam, Kalanithi [1 ]
机构：
[1] Malaysian Palm Oil Board, Prod Dev & Advisory Serv Div, Persiaran Inst 6, Kajang 43000, Selangor Darul, Malaysia
[2] Int Med Univ, Sch Pharm, Dept Pharmaceut Chem, 126,Jalan 19-155B, Kuala Lumpur 57000, Malaysia
[3] Int Med Univ, Sch Med, Dept Human Biol, 126,Jalan 19-155B, Kuala Lumpur 57000, Malaysia
来源：
NANOMEDICINE | 2017年 / 12卷 / 20期
关键词：
6-O-palmitoyl-ascorbic acid; active targeting; breast cancer; niosomes; tocotrienols; transferrin; BREAST-CANCER CELLS; GAMMA-TOCOTRIENOL; RICH FRACTION; IN-VIVO; DELTA-TOCOTRIENOL; SIGNALING PATHWAY; CELLULAR UPTAKE; SOLID TUMORS; PALM OIL; NANOPARTICLES;
D O I：
10.2217/nnm-2017-0182
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer. Materials & methods: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy. Results: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1.5-fold reduction in IC50 value compared with nonformulated T3. In vivo, the average tumor volume of mice treated with tumor-targeted niosomes was 12-fold lower than that of untreated group, accompanied by marked downregulation of three genes involved in metastasis. Conclusion: Findings suggested that tumor-targeted niosomes served as promising delivery system for T3 in cancer therapy.
引用
收藏
页码：2487 / 2502
页数：16
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