New HA 14-1 analogues: synthesis of 2-amino-4-cyano-4H-chromenes

被引：66

作者：

Moafi, Leila ^{[1
]}

Ahadi, Somayeh ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期

关键词：

Multicomponent; Chromene; Malononitrile; Chromeno[2,3-d]pyrimidine; Salicylaldehyde; ONE-POT SYNTHESIS; 3-COMPONENT REACTION; 4H-CHROMENE DERIVATIVES; EFFICIENT SYNTHESIS; BIOLOGICAL-ACTIVITY; BCL-2; PROTEIN; SALICYLALDEHYDES; ISOCYANIDES; APOPTOSIS; CHEMISTRY;

D O I：

10.1016/j.tetlet.2010.09.090

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2-amino-4-cyano-4H-chromene derivatives as new HA 14-1 analogues by a simple and efficient method is reported. In addition, the reaction of 2-amino-2H-chromene-3-carbonitriles, salicylaldehydes and amines results in the formation of new chromeno[2,3-d]pyrimidine derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6270 / 6274

页数：5

共 34 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].

Adams, JM ;

Cory, S .

SCIENCE, 1998, 281 (5381) :1322-1326

[2] One-pot synthesis and antibacterial activities of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-dione derivatives [J].

Bazgir, Ayoob ;

Khanaposhtani, Maryam Mohammadi ;

Soorki, Ali Abolhasani .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (21) :5800-5803

[3] A novel three-component method for the synthesis of triazolo[1,2-a]indazole-triones [J].

Bazgir, Ayoob ;

Seyyedhamzeh, Mozhdeh ;

Yasaei, Zahra ;

Mirzaei, Peiman .

TETRAHEDRON LETTERS, 2007, 48 (50) :8790-8794

[4] Simple coumarins and analogues in medicinal chemistry: Occurrence, synthesis and biological activity [J].

Borges, F ;

Roleira, F ;

Milhazes, N ;

Santana, L ;

Uriarte, E .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (08) :887-916

[5] Parallel liquid-phase synthesis of benzopyrano[2,3-d]pyrimidine libraries [J].

Borisov, Alexander V. ;

Dzhavakhishvili, Sergey G. ;

Zhuravel, Irina O. ;

Kovalenko, Sergiy M. ;

Nikitchenko, Victor M. .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 9 (01) :5-8

[6] The condensation of salicylaldehydes and malononitrile revisited:: Synthesis of new dimeric chromene derivatives [J].

Costa, Marta ;

Areias, Filipe ;

Abrunhosa, Luis ;

Venancio, Armando ;

Proenca, Fernanda .

JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (05) :1954-1962

[7] Chemistry and biological activity of natural and synthetic prenyloxycoumarins [J].

Curini, M ;

Cravotto, G ;

Epifano, F ;

Giannone, G .

CURRENT MEDICINAL CHEMISTRY, 2006, 13 (02) :199-222

[8] A novel reaction of 6-amino-uracils and isatins [J].

Dabiri, Minoo ;

Azimi, Seyyedeh Cobra ;

Khavasi, Hamid Reza ;

Bazgir, Ayoob .

TETRAHEDRON, 2008, 64 (30-31) :7307-7311

[9]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[10]

2-U

← 1 2 3 4 →