The wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes

被引：743
作者：
Beraldo, H [1 ]
Gambino, D
机构：
[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Republica, Fac Quim, Dept Estrella Campos, Catedra Quim Inorgan, Montevideo, Uruguay
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 01期
关键词：
semicarbazones; thiosemicarbazones; biological activity; pharmacological applications; bioactive metal complexes; mechanisms of action;
D O I：
10.2174/1389557043487484
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.
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收藏
页码：31 / 39
页数：9
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