Localization-dictated function for METTL3

被引：4

作者：

Delaunay, Sylvain ^{[1
]}

Frye, Michaela ^{[1
]}

机构：

[1] German Canc Res Ctr Deutsch Krebsforschungszentru, Heidelberg, Germany

来源：

NATURE CELL BIOLOGY | 2022年 / 24卷 / 08期

关键词：

MESSENGER-RNA; TRANSLATION;

D O I：

10.1038/s41556-022-00972-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aberrant subcellular localization of proteins contributes to the pathogenesis of cancer. A study now reports that the mis-localization of METTL3, a nuclear N-6-adenosine methyltransferase, to the cytoplasm promotes gastric cancer by enhancing mRNA translation of a subset of oncogenes, independently of the N-6-methyladenosine (m(6)A) modification.

引用

页码：1188 / 1189

页数：2

共 12 条

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