Megakaryocytopoiesis: Growth factors, cell cycle and gene expression

被引：0

作者：

Baatout, S

机构：

[1] CEN SCK, Radiobiol Lab, Belgian Nucl Energy Study Ctr, B-2400 Mol, Belgium

[2] UCL, Lab Expt Hematol & Oncol, Brussels, Belgium

来源：

ANTICANCER RESEARCH | 1998年 / 18卷 / 3B期

关键词：

megakaryocyte regulation; growth factor; cell cycle; gene expression; polyploidization;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Megakaryocytopoiesis is the process prior to the release of platelets into the blood vessel. It is regulated by a variety of cell-cell interactions and by a number of cytokines with either stimulatory or inhibitory effects. It is the intent of this review to give an overview of the regulation of megakaryocytopoiesis in a comprehensive analysis of the most recent advances, with special emphasis on cytokines that stimulate or inhibit megakaryocytopoiesis and on the cell cycle and gene expression of megakaryocytes. A chapter will be devoted to the abnormal megakaryocytopoiesis in hematological diseases and, in particular in myeloproliferative syndromes.

引用

页码：1871 / 1882

页数：12

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