Bovine serum albumin gel/polyelectrolyte complex of hyaluronic acid and chitosan based microcarriers for Sorafenib targeted delivery

被引：18

作者：

Pascalau, Violeta ^{[1
]}

Tertis, Mihaela ^{[2
]}

Pall, Emoke ^{[3
]}

Suciu, Maria ^{[4
]}

Marinca, Traian ^{[1
]}

Pustan, Marius ^{[1
]}

Merie, Violeta ^{[1
]}

Rus, Iulia ^{[2
]}

Moldovan, Cristian ^{[5
]}

Topala, Tamara ^{[2
]}

Pavel, Codruta ^{[1
]}

Popa, Catalin ^{[1
]}

机构：

[1] Tech Univ Cluj apoca, Cluj Napoca, Romania

[2] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, 8 Victor Babes St, Cluj Napoca 400012, Romania

[3] Univ Agr Sci & Vet Med Cluj Napoca, Cluj Napoca, Romania

[4] Natl Inst Res & Dev Isotop & Mol Technol, Cluj Napoca, Romania

[5] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, MedFuture Res Ctr Adv Med, Cluj Napoca, Romania

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2020年 / 137卷 / 34期

关键词：

BSA; chitosan; hyaluronic acid; microcapsules; Sorafenib; HEPATOCELLULAR-CARCINOMA; MUCOADHESIVE PROPERTIES; DRUG-DELIVERY; CO-DELIVERY; MICROSPHERES; NANOPARTICLES; CANCER; CURCUMIN;

D O I：

10.1002/app.49002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The development of systems for targeted delivery of Sorafenib in unresectable hepatocellular carcinoma to reduce the systemic toxicity is a challenge. In our article, we successfully prepared core-shell microcapsules based on bovine serum albumin gel with polyelectrolyte complex multilayer shell of polysaccharides with opposite charges, hyaluronic acid, and chitosan, encapsulating Sorafenib, as targeting delivery system for improved hepatocellular carcinoma therapy. A bovine serum albumin gel core was formed by a method based on a sacrificial CaCO3 template, followed by the multilayer shell build-up of Ca2+ cross-linked hyaluronic acid hydrogel, and subsequently alternating multilayers of the polyelectrolyte complex formed between hyaluronic acid and chitosan. The following techniques: Fourier-transform infrared and UV-Vis spectroscopy, X-ray diffraction, differential scanning calorimetry, confocal laser scanning microscopy, atomic force microscopy, and scanning electron microscopy were used for the physicochemical characterization. These tests revealed the spherical shape of core-shell type, the micro-size, as well as the composition of microcapsules after their synthesis and proved the successful encapsulation and release of the drug. The promising results regarding encapsulation efficiency, Sorafenib release profile and cytotoxicity on HepG2 and mesenchymal stem cells, recommend Sorafenib loaded microcapsules as suitable targeted drug carriers for further in vivo studies for hepatocellular carcinoma therapy.

引用

页数：16

共 42 条

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