A photoacoustic finder fully integrated with a solid-state dye laser and transparent ultrasound transducer

被引：56

作者：

Park, Byullee ^{[1
,2
]}

Han, Moongyu ^{[1
,2
]}

Park, Jeongwoo ^{[1
,2
]}

Kim, Taejeong ^{[3
]}

Ryu, Hanyoung ^{[4
]}

Seo, Youngseok ^{[4
]}

Kim, Won Jong ^{[3
]}

Kim, Hyung Ham ^{[1
,2
]}

Kim, Chulhong ^{[1
,2
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Elect Engn, Convergence IT Engn, Mech Engn, 77 Cheongam Ro, Pohang 37673, South Korea

[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Med Device Innovat Ctr, 77 Cheongam Ro, Pohang 37673, South Korea

[3] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Postech Catholic Biomed Engn Inst, Dept Chem, 77 Cheongam Ro, Pohang 37673, South Korea

[4] Wontech Co Ltd, R&D Ctr, Daejeon 34028, South Korea

来源：

PHOTOACOUSTICS | 2021年 / 23卷

基金：

新加坡国家研究基金会;

关键词：

Photoacoustic sensing; Transparent ultrasound transducer; Solid-state dye laser; Melanoma; Sentinel lymph node; LYMPH-NODE BIOPSY; INDOCYANINE GREEN FLUORESCENCE; BREAST-CANCER; RADIOISOTOPE; EXPANSION; PROBE;

D O I：

10.1016/j.pacs.2021.100290

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The standard-of-care for evaluating lymph node status in breast cancers and melanoma metastasis is sentinel lymph node (SLN) assessment performed with a handheld gamma probe and radioisotopes. However, this method inevitably exposes patients and physicians to radiation, and the special facilities required limit its accessibility. Here, we demonstrate a non-ionizing, cost-effective, handheld photoacoustic finder (PAF) fully integrated with a solid-state dye laser and transparent ultrasound transducer (TUT). The solid-state dye laser handpiece is coaxially aligned with the spherically focused TUT. The integrated finder readily detected photo acoustic signals from a tube filled with methylene blue (MB) beneath a 22 mm thick layer of chicken tissue. In live animals, we also photoacoustically detected both SLNs injected with MB and subcutaneously injected melanomas. We believe that our radiation-free and inexpensive PAF can play a vital role in SLN assessment.

引用

页数：7

共 59 条

[11] Sentinel lymph node biopsy as the new standard of care in the surgical treatment for breast cancer [J].