Preparation and the Antibacterial Activity of AgNPs/PLGA-PEG-PLGA Composite Hydrogel

The PLGA-PEG-PLGA triblock thermosensitive hydrogel was synthesized via ring opening copolymerization of D, L-lactide (D, L-LA) and glycolide (GA) with PEG1000 as a macromolecular initiator. H NMR spectrum of the copolymer was obtained to confirm the structure and composition. Silver nanoparticles which prepared by reduction of silver nitrate were mixed with the prepared PLGA-PEG-PLGA three block copolymer hydrogel. A new type of AgNPs/PLGA-PEG-PLGA hydrogel was prepared. The properties of AgNPs/PLGA-PEG-PLGA composite hydrogels were characterized. The AgNP s/PLGA-PEG-PLGA composite hydrogel still has a temperature sensitive property, and the sol-gel phase transition occurs with the increase of temperature. Novel hydrogel can be sustained release of silver nanoparticles to play antibacterial properties. In vitro biocompatibility experiments showed that the novel AgNPs/PLGA-PEG-PLGA hydrogel has good biocompatibility and no cytotoxicity. It is a new type of composite hydrogel with good application prospect.