Expression of interleukin 6 and its receptor in human gastric and colorectal cancers

被引：44

作者：

Matsuo, K

Oka, M

Murase, K

Soda, H

Isomoto, H

Takeshima, F

Mizuta, Y

Murata, I

Kohno, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan

[2] Nagasaki Univ, Grad Sch Pharmaceut Sci, Dept Pharmacotherapeut, Nagasaki 852, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2003年 / 31卷 / 02期

关键词：

cytokine; interleukin; 6; receptor; gastric cancer; colorectal cancer;

D O I：

10.1177/147323000303100202

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions. The present study was designed to determine the expression of IL-6 and its receptor (IL-6R) in human gastric and colorectal cancers. Nine gastric- and nine colorectal cancer cell lines were analysed. The IL-6 gene was expressed in two gastric cancer cell lines and one colorectal cancer cell line; however, most of the cancer cell lines studied expressed the IL-6R gene. The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< similar to100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines (< similar to50 pg/ml). These results suggest that IL-6 may act in a paracrine fashion rather than an autocrine fashion in these cell lines.

引用

页码：69 / 75

页数：7

共 28 条

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