Chronic stress and Alzheimer's disease

被引：10
作者：
Mohammadi, Shima [1 ]
Zandi, Milad [2 ]
Dousti Kataj, Parviz [1 ]
Karimi Zandi, Leila [1 ]
机构：
[1] Univ Tehran Med Sci, Sch Adv Technol Med, Neurosci & Addict Studies Dept, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran, Iran
来源：
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | 2022年 / 69卷 / 04期
关键词：
Alzheimer; neural pathways; neurodegenerative disease; stress; CORTICOTROPIN-RELEASING-FACTOR; AMYLOID PRECURSOR PROTEIN; MOUSE MODEL; COGNITIVE DECLINE; TAU PHOSPHORYLATION; INSULIN-RESISTANCE; ALLOSTATIC LOAD; BETA; BRAIN; CORTISOL;
D O I：
10.1002/bab.2216
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stress is a key factor in the development and progress of diseases. In neurodegenerative conditions, stress management can play an important role in maintaining the quality of life and the capacity to improve. Neurodegenerative diseases, including Alzheimer's disease, cause the motor and cognitive malfunctions that are spontaneously stressful and also can disturb the neural circuits that promote stress responses. The interruption of those circuits leads to aggressive and inappropriate behavior. In addition, stress contributes to illness and may exacerbate symptoms. In this review, we present stress-activated neural pathways involved in Alzheimer's disease from a clinical and experimental point of view, as well as supportive drugs and therapies.
引用
收藏
页码：1451 / 1458
页数：8
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