RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation

被引：74

作者：

Jiang, Lin-Jia ^{[1
,2
,3
,4
]}

Zhang, Nan-Nan ^{[1
,2
,3
]}

Ding, Fei ^{[1
,2
,3
]}

Li, Xian-Yang ^{[1
,2
,3
]}

Chen, Lei ^{[1
,2
,3
]}

Zhang, Hong-Xin ^{[4
,5
]}

Zhang, Wu ^{[1
,2
,3
,4
,6
]}

Chen, Sai-Juan ^{[1
,2
,3
]}

Wang, Zhu-Gang ^{[4
,5
]}

Li, Jun-Min ^{[1
,2
,3
]}

Chen, Zhu ^{[1
,2
,3
]}

Zhu, Jiang ^{[1
,2
,3
,4
,6
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, State Key Lab Med Genom, Shanghai 200025, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China

[3] Rui Jin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China

[4] Shanghai E Inst Model Organisms, Shanghai 200025, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Dept Med Genet, Shanghai 200025, Peoples R China

[6] Shanghai Inst Stem Cells, Shanghai 200025, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2011年 / 108卷 / 05期

关键词：

ACID-INDUCED DIFFERENTIATION; RETINOIC ACID; IFN-GAMMA; RIG-I; TRANSCRIPTION FACTORS; UP-REGULATION; APL CELLS; EXPRESSION; PROTEIN; PHOSPHORYLATION;

D O I：

10.1073/pnas.1019059108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-beta promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or RA signaling process in acute myeloid leukemia (AML) cells, however, where obvious RIG-I induction is observed. Here, we show that the RIG-I induction functionally contributes to IFN-alpha plus RA-triggered growth inhibition of AML cells. Interestingly, although RIG-I induction itself is under the regulation of STAT1, a major IFN intracellular signal mediator, under circumstances in which it does not stimulate IPS-1, it conversely augments STAT1 activation to induce IFN-stimulatory gene expression and inhibit leukemia cell proliferation. Thus, our results unveil a previously undescribed RIG-I activity in regulating the cellular proliferation of leukemia cells via STAT1, which is independent of its classic role of sensing viral invasion to trigger type I IFN transcription.

引用

页码：1897 / 1902

页数：6

共 36 条

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