Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

被引：147

作者：

Lampe, Leonie ^{[1
,2
]}

Kharabian-Masouleh, Shahrzad ^{[1
]}

Kynast, Jana ^{[1
]}

Arelin, Katrin ^{[1
]}

Steele, Christopher J. ^{[1
,3
]}

Loeffler, Markus ^{[4
]}

Witte, A. Veronica ^{[1
]}

Schroeter, Matthias L. ^{[1
,2
]}

Villringer, Arno ^{[1
,2
]}

Bazin, Pierre-Louis ^{[1
]}

机构：

[1] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Stephanstr 1a, D-04103 Leipzig, Germany

[2] Univ Hosp Leipzig, Clin Cognit Neurol, Leipzig, Germany

[3] McGill Univ, Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada

[4] Univ Leipzig, Inst Med Informat Stat & Epidemiol IMISE, Leipzig, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2019年 / 39卷 / 01期

关键词：

White matter hyperintensities; cerebral small vessel disease; cognitive impairment; brain atrophy; brain aging; SMALL VESSEL DISEASE; MICROSTRUCTURAL INTEGRITY; EXECUTIVE FUNCTION; STROKE; DEMENTIA; PEOPLE; IMPACT; RISK;

D O I：

10.1177/0271678X17740501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort (n = 702, age range 60 - 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter-including the corticospinal tract-compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.

引用

页码：36 / 43

页数：8

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