Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

被引：145

作者：

Lampe, Leonie ^{[1
,2
]}

Kharabian-Masouleh, Shahrzad ^{[1
]}

Kynast, Jana ^{[1
]}

Arelin, Katrin ^{[1
]}

Steele, Christopher J. ^{[1
,3
]}

Loeffler, Markus ^{[4
]}

Witte, A. Veronica ^{[1
]}

Schroeter, Matthias L. ^{[1
,2
]}

Villringer, Arno ^{[1
,2
]}

Bazin, Pierre-Louis ^{[1
]}

机构：

[1] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Stephanstr 1a, D-04103 Leipzig, Germany

[2] Univ Hosp Leipzig, Clin Cognit Neurol, Leipzig, Germany

[3] McGill Univ, Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada

[4] Univ Leipzig, Inst Med Informat Stat & Epidemiol IMISE, Leipzig, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2019年 / 39卷 / 01期

关键词：

White matter hyperintensities; cerebral small vessel disease; cognitive impairment; brain atrophy; brain aging; SMALL VESSEL DISEASE; MICROSTRUCTURAL INTEGRITY; EXECUTIVE FUNCTION; STROKE; DEMENTIA; PEOPLE; IMPACT; RISK;

D O I：

10.1177/0271678X17740501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort (n = 702, age range 60 - 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter-including the corticospinal tract-compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.

引用

页码：36 / 43

页数：8

共 30 条

[1] Executive function and the frontal lobes: A meta-analytic review [J].

Alvarez, Julie A. ;

Emory, Eugene .

NEUROPSYCHOLOGY REVIEW, 2006, 16 (01) :17-42

[2]

[Anonymous], 2015, R: A Language and Environment for Statistical Computing, V55, P275

[3] Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain [J].

Avants, B. B. ;

Epstein, C. L. ;

Grossman, M. ;

Gee, J. C. .

MEDICAL IMAGE ANALYSIS, 2008, 12 (01) :26-41

[4] Lesion location and cognitive impact of cerebral small vessel disease [J].

Biesbroek, J. Matthijs ;

Weaver, Nick A. ;

Biessels, Geert Jan .

CLINICAL SCIENCE, 2017, 131 (08) :715-728

[5] Association between Subcortical Vascular Lesion Location and Cognition: A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study [J].

Biesbroek, J. Matthijs ;

Kuijf, Hugo J. ;

van der Graaf, Yolanda ;

Vincken, Koen L. ;

Postma, Albert ;

Mali, Willem P. T. M. ;

Biessels, Geert J. ;

Geerlings, Mirjam I. .

PLOS ONE, 2013, 8 (04)

[6] White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients [J].

Burton, EJ ;

Kenny, RA ;

O'Brien, J ;

Stephens, S ;

Bradbury, M ;

Rowan, E ;

Kalaria, R ;

Firbank, M ;

Wesnes, K ;

Ballard, C .

STROKE, 2004, 35 (06) :1270-1275

[7] Longitudinal multiple sclerosis lesion segmentation: Resource and challenge [J].

Carass, Aaron ;

Roy, Snehashis ;

Jog, Amod ;

Cuzzocreo, Jennifer L. ;

Magrath, Elizabeth ;

Gherman, Adrian ;

Button, Julia ;

Nguyen, James ;

Prados, Ferran ;

Sudre, Carole H. ;

Cardoso, Manuel Jorge ;

Cawley, Niamh ;

Ciccarelli, Olga ;

Wheeler-Kingshott, Claudia A. M. ;

Ourselin, Sebastien ;

Catanese, Laurence ;

Deshpande, Hrishikesh ;

Maurel, Pierre ;

Commowick, Olivier ;

Barillot, Christian ;

Tomas-Fernandez, Xavier ;

Warfield, Simon K. ;

Vaidya, Suthirth ;

Chunduru, Abhijith ;

Muthuganapathy, Ramanathan ;

Krishnamurthi, Ganapathy ;

Jesson, Andrew ;

Arbel, Tal ;

Maier, Oskar ;

Handeles, Heinz ;

Iheme, Leonardo O. ;

Unay, Devrim ;

Jain, Saurabh ;

Sima, Diana M. ;

Smeets, Dirk ;

Ghafoorian, Mohsen ;

Platel, Bram ;

Birenbaum, Ariel ;

Greenspan, Hayit ;

Bazin, Pierre-Louis ;

Calabresi, Peter A. ;

Crainiceanu, Ciprian M. ;

Ellingsen, Lotta M. ;

Reich, Daniel S. ;

Prince, Jerry L. ;

Pham, Dzung L. .

NEUROIMAGE, 2017, 148 :77-102

[8] Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study [J].

de Leeuw, FE ;

de Groot, JC ;

Achten, E ;

Oudkerk, M ;

Ramos, LMP ;

Heijboer, R ;

Hofman, A ;

Jolles, J ;

van Gijn, J ;

Breteler, MMB .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (01) :9-14

[9] Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke -: The PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy [J].

Dufouil, C ;

Chalmers, J ;

Coskun, O ;

Besançon, V ;

Bousser, MG ;

Guillon, P ;

MacMahon, S ;

Mazoyer, B ;

Neal, B ;

Woodward, M ;

Tzourio-Mazoyer, N ;

Tzourio, C .

CIRCULATION, 2005, 112 (11) :1644-1650

[10] Cigarette smoking is associated with reduced microstructural integrity of cerebral white matter [J].

Gons, Rob A. R. ;

van Norden, Anouk G. W. ;

de laat, Karlijn F. ;

van Oudheusden, Lucas J. B. ;

van Uden, Inge W. M. ;

Zwiers, Marcel P. ;

Norris, David G. ;

de Leeuw, Frank-Erik .

BRAIN, 2011, 134 :2116-2124

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