A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation

被引：2

作者：

Kim, Miriam ^{[1
]}

Rao, Seema ^{[1
,3
]}

Eickhoff, Jens C. ^{[2
]}

DeSantes, Kenneth B. ^{[1
]}

Capitini, Christian M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pediat, Carbone Canc Ctr, Sch Med & Publ Hlth, Madison, WI USA

[2] Univ Wisconsin, Dept Biostat & Med Informat, Carbone Canc Ctr, Sch Med & Publ Hlth, Madison, WI USA

[3] Baylor Coll Med, Dept Pediat, Texas Childrens Canc & Hematol Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 02期

基金：

美国国家卫生研究院;

关键词：

venoocclusive disease; BMT; stem cell transplantation; sinusoidal obstruction syndrome; antithrombin III; BONE-MARROW-TRANSPLANTATION; VENOOCCLUSIVE DISEASE; PREVENTION; TRIAL; LIVER;

D O I：

10.1097/MPH.0000000000001422

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Twelve of 13 patients who were treated with ATIII therapy alone had complete resolution of SOS, including 4 of 5 children with severe SOS. In this limited cohort, ATIII was safe and successfully prevented progression of hepatic SOS following HSCT in the majority of children at our center.

引用

页码：145 / 148

页数：4

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